Results 61 to 70 of about 7,569,463 (308)
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
Oscillations of First Order Delay Dynamic Equations
, 2006 Stavroulakis, Ioannis/0000-0002-4810-0540Consider the first order linear delay dynamic equation of the forms x(Delta)(t) + p(t)x(tau(t)) = 0. (E) New oscillation criteria are established which contain well-known criteria for delay differential and ...
Sahiner, Y., Stavroulakis, I. P.
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
OSCILLATION AND NONOSCILLATION OF FIRST-ORDER DYNAMIC EQUATIONS WITH POSITIVE AND NEGATIVE COEFFICIENTS [PDF]
, 2009 In this article, we investigate oscillatory nature of all solutions of a class of delay dynamic equations including positive and negative coefficients. Also we give a nonoscillation criterion for this class of delay dynamic equations.
Ocalan, Ozkan, Karpuz, Basak
core +1 more source
Dynamic time series binary choice [PDF]
This paper considers dynamic time series binary choice models. It proves near epoch dependence and strong mixing for the dynamic binary choice model with correlated errors.
Robert M. de Jong, Tiemen Woutersen
core +2 more sources
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Mistuned Dynamic Response Analysis of Series Mechanism
Jixie chuandong, 2016 The series periodic mechanism has mistuned dynamic response and peculiarity. The series mechanism model is set up based on theory and method of multi- body dynamics.
Yu Linchong, Lin Zhishu, Lin Xingyan
doaj
Semi-parametric dynamic time series modelling with applications to detecting neural dynamics [PDF]
, 2007 This paper illustrates the theory and applications of a methodology for non-stationary time series modeling which combines sequential parametric Bayesian estimation with non-parametric change-point testing.
Smith, J. Q., Rigat, Fabio
core