Results 71 to 80 of about 638,996 (262)

TSEE: an elastic embedding method to visualize the dynamic gene expression patterns of time series single-cell RNA sequencing data

BMC Genomics, 2019
Background Time series single-cell RNA sequencing (scRNA-seq) data are emerging. However, the analysis of time series scRNA-seq data could be compromised by 1) distortion created by assorted sources of data collection and generation across time samples ...
Shaokun An, Liang Ma, Lin Wan
doaj   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

CONSIDERATIONS REGARDING THE EVOLUTION OF GROSS DOMESTIC EXPENDITURE ON R&D (GERD) IN ROMANIA AND EU COUNTRIES. PART II – DYNAMIC RHYTHMS [PDF]

Journal of Defense Resources Management
In this paper we have analyzed the evolution of Gross Domestic Expenditure on R&D (GERD) in Romania and EU countries on the last ten years with the available data (2013-2022) provided by the EUROSTAT database.
Cristina ANTONOAIE
doaj  

Dynamic Performance of Concrete Considering Initial Stresses and Creep

Железобетонные конструкции
In accidental design situations, the loading mode of reinforced concrete structures includes two typical stages such as long-term deformation under constant or slowly varying load and dynamic impact.
S. Yu. Savin, M. Z. Sharipov
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Research on Correlation Analysis for Multidimensional Time Series Based on the Evolution Synchronization of Network Topology

Mathematics
We apply the inherent dynamic consistency of a dynamic system as the basis for correlation analysis among different variables in a system. We use network analysis to measure the correlativity of multiple variables, find the interdependence between ...
Hongduo Cao, Ying Li
doaj   +1 more source

Similarity Measure Based on Incremental Warping Window for Time Series Data Mining

IEEE Access, 2019
A similarity measure is one of the most important tasks in the fields of time series data mining. Its quality often affects the efficiency and effectiveness of the related algorithms that need to measure the similarity between two time series in advance.
Hailin Li, Cheng Wang
doaj   +1 more source

Dynamic voltage scaling for series hybrid amplifiers

Microelectronics Journal, 2013
We present an optimization of the voltage scaling algorithm in low power audio class G amplifier for headphones application toallow longer playback time. The optimization approach minimizes the voltage difference between the internal audio amplifierpower supply and its output signal over a large range of operating conditions. The modeling is based on a
Patrice Russo, Firas Yengui, Gaël Pillonnet, Sophie Taupin, Nacer Abouchi   +4 more
openaire   +3 more sources

Dynamic Factor Graphs for Time Series Modeling [PDF]

, 2009
This article presents a method for training Dynamic Factor Graphs (DFG) with continuous latent state variables. A DFG includes factors modeling joint probabilities between hidden and observed variables, and factors modeling dynamical constraints on hidden variables. The DFG assigns a scalar energy to each configuration of hidden and observed variables.
Piotr Mirowski, Yann LeCun
openaire   +1 more source