Results 91 to 100 of about 1,034,587 (282)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Spectrum Handoff pada Teknologi Dynamic Spectrum Access and Sharing untuk Radio Kognitif

open access: yesJurnal Teknik ITS, 2012
Salah satu teknik dalam dynamic spectrum access and sharing yang diimplementasikan pada sistem radio kognitif adalah spektrum handoff. Spektrum handoff merupakan salah satu dari tiga bagian penting dalam teknologi radio kognitif selain spektrum sensing ...
Muhammad Nur Rahman   +2 more
doaj  

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Manajemen Spectrum Sharing Terdistribusi pada Teknologi Dynamic Spectrum Access untuk Radio Kognitif

open access: yesJurnal Teknik ITS, 2012
Tuntutan komunikasi nirkabel yang handal dan kapasitas sistem yang tinggi tidak terlepas dari ketersediaan resource berupa spektrum frekuensi yang cukup. Penelitian pada tugas akhir ini adalah simulasi penerapan mekanisme spectrum sharing pada arsitektur
Ibrahim Zein Abdillah   +2 more
doaj  

Meeting Real-Time Constraint of Spectrum Management in TV Black-Space Access [PDF]

open access: yes, 2017
The TV set feedback feature standardized in the next generation TV system, ATSC 3.0, would enable opportunistic access of active TV channels in future Cognitive Radio Networks.
Zhao, Zhongyuan
core   +3 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Database-Assisted Spectrum Access in Dynamic Networks: A Distributed Learning Solution

open access: yesIEEE Access, 2015
This paper investigates the problem of database-assisted spectrum access in dynamic TV white spectrum networks, in which the active user set is varying.
Yuhua Xu, Yitao Xu, Alagan Anpalagan
doaj   +1 more source

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