Results 91 to 100 of about 2,169,888 (325)

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Learning to read as the formation of a dynamic system: Evidence for dynamic stability in phonological recoding

Frontiers in Psychology, 2014
Two aspects of dynamic systems approaches that are pertinent to developmental models of reading are the emergence of a system with self-organizing characteristics, and its evolution over time to a stable state that is not easily modified or perturbed ...
Claire Marie Fletcher-Flinn
doaj   +1 more source

Damage spreading and dynamic stability of kinetic Ising models

, 1996
We investigate how the time evolution of different kinetic Ising models depends on the initial conditions of the dynamics. To this end we consider the simultaneous evolution of two identical systems subjected to the same thermal noise. We derive a master
Coniglio A, Costa U, Derrida B, Glotzer S C, Gollinelli O, Grassberger P, Grassberger P, Schuster H G, Thomas Vojta, Vojta T, Wang F, Wappler T   +11 more
core   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Assessment of yield stability in sugarcane genotypes using non-parametric methods

Agronomía Colombiana, 2015
The evaluation of performance stability and high yields is essential for yield trials in different environments. This study was carried out to identifysugarcane genotypesthat have both a high mean cane yield, mesured in tons of cane per hectare (TCH ...
Ramón Rea, Orlando De Sousa-Vieira, Alida Díaz, Miguel Ramón, Rosaura Briceño, José George, Jhonny Demey   +6 more
doaj   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Dinámica de la frecuencia del Sistema InterconectadDinámica Interconectado Ecuador-Colombia; Dinamic of the frequency of the interconected system Ecuador- Colombia

Revista Científica de Ingeniería Energética, 2011
En el presente trabajo se propone un procedimiento para estudiar la dinámica de lafrecuencia del sistema interconectado Ecuador-Colombia, ante la salida de unidadesgeneradoras cuando no se dispone de la información necesaria del sistema el ...
Marcelo Arias Castañeda, Antonio Martínez García   +1 more
doaj  

A Design Fuzzy Logic Controller for a Permanent Magnet Wind Generator to Enhance the Dynamic Stability of Wind Farms

Applied Sciences, 2012
In this paper, a design fuzzy logic controller for a variable speed permanent magnet wind generator connected to a grid system through a LC-filter is proposed.
Marwan Rosyadi, S. M. Muyeen, Rion Takahashi, Junji Tamura   +3 more
doaj   +1 more source

The importance of steady and dynamic inflow on the stability of rotor-body systems [PDF]

The induced flow field of a rotor responds in a dynamic fashion to oscillations in rotor lift. This was long known to affect the stability and control derivatives of the rotor.
Peters, David A.
core   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source