Results 121 to 130 of about 6,987,863 (341)

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Neuromuscular synergy characteristics of Tai Chi leg stirrup movements: optimal coordination patterns throughout various phases

Frontiers in Bioengineering and Biotechnology
ObjectiveTo investigate the neuromuscular activity characteristics of Tai Chi athletes and identify optimal muscle synergy patterns.MethodData were collected from 12 elite Tai Chi athletes using a Vicon motion capture system, a Kistler 3D force plate ...
Xiaopei Zhang, Mengyao Jia, Mengyao Jia, Yong Ke, Jihe Zhou   +4 more
doaj   +1 more source

A note on correlation functions and stability in dynamical systems [PDF]

, 1954
C. R. Putnam
openalex   +1 more source

Time, the final frontier

Molecular Oncology, EarlyView.
This article advocates integrating temporal dynamics into cancer research. Rather than relying on static snapshots, researchers should increasingly consider adopting dynamic methods—such as live imaging, temporal omics, and liquid biopsies—to track how tumors evolve over time.
Gautier Follain, Michal Dibus, Omkar Joshi, Guillaume Jacquemet   +3 more
wiley   +1 more source

High-Density Behavior and Dynamical Stability of Neutron Star Models. [PDF]

, 1964
C. W. Misner, H. S. Zapolsky
openalex   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Learning to read as the formation of a dynamic system: Evidence for dynamic stability in phonological recoding

Frontiers in Psychology, 2014
Two aspects of dynamic systems approaches that are pertinent to developmental models of reading are the emergence of a system with self-organizing characteristics, and its evolution over time to a stable state that is not easily modified or perturbed ...
Claire Marie Fletcher-Flinn
doaj   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Experimental studies of the influence of a gyroscopic damping system on the aeroelastic characteristics of a large aircraft model with elastic pylon-mounted engines under the wing

Научный вестник МГТУ ГА
During production of modern large transport aircraft, engine arrangement mounted on the elastic pylons under the wing is widely used. This arrangement of engines has certain advantages, however, there are also significant dynamic features due to the fact
Y. V. Petrov, M. V. Semakova, N. N. Medvedeva, V. G. Ugreninov   +3 more
doaj   +1 more source

Discussion: “On the Almost Sure Stability of Linear Dynamic Systems With Stochastic Coefficients” (Caughey, T. K., and Gray, Jr., A. H., 1965, ASME J. Appl. Mech., 32, pp. 365–372) [PDF]

, 1966
C. B. Mehr, P. K. C. WANG
openalex   +1 more source