Results 51 to 60 of about 2,947,910 (287)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Large eddy simulation of dynamic stall over an airfoil and its control with plasma actuator

AIP Advances, 2023
The purpose of this study is to investigate deep dynamic stall over a pitching National Advisory Committee for Aeronautics 0015 airfoil and its control with an alternating current dielectric barrier discharge (AC-DBD) plasma actuator by means of large ...
Hengyang Zhang, Haocheng Yu, Ao Zhang, Jianguo Zheng   +3 more
doaj   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source

Numerical Investigation of a Dynamic Stall on a Single Rotating Blade

Aerospace, 2021
Dynamic stall is a phenomenon on the retreating blade of a helicopter which can lead to excessive control loads. In order to understand dynamic stall and fill the gap between the investigations on pitching wings and full helicopter rotor blades, a ...
Yin Ruan, Manfred Hajek
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Dynamic Stall Characteristics of Thick Wind Turbine Airfoils

Wind Energy
This paper studies the dynamic stall characteristics of thick flatback and nonflatback wind turbine airfoils. Two airfoils with a maximum thickness of 35% were studied, with trailing edge thicknesses of 2% and 10%, respectively.
Mehdi Doosttalab, Carlos Simao Ferreira, Daniele Ragni, Wei Yu, Christof Rautmann   +4 more
doaj   +1 more source

Dynamic Stall Mechanisms of Pitching Airfoil: IDDES Study Across Different Mach Numbers

Applied Sciences
This study investigates dynamic stall mechanisms of a pitching NACA 0012 airfoil through high-fidelity computational fluid dynamics (CFD) simulations.
Simeng Jing, Fan Lu, Li Ma, Qijun Zhao, Guoqing Zhao   +4 more
doaj   +1 more source

Near Stall Unsteady Flow Responses to Morphing Flap Deflections

Fluids, 2021
The unsteady flow characteristics and responses of an NACA 0012 airfoil fitted with a bio-inspired morphing trailing edge flap (TEF) at near-stall angles of attack (AoA) undergoing downward deflections are investigated at a Reynolds number of 0.62 × 106 ...
Chawki Abdessemed, Yufeng Yao, Abdessalem Bouferrouk   +2 more
doaj   +1 more source

Current Status and Challenges in Data Collection for Aerospace Coatings Deposited by Plasma Spraying

Advanced Engineering Materials, EarlyView.
An innovative approach has been integrated into the GRENAT project to optimize plasma spraying and coating performance. Raw materials are accelerated and melted in the plasma generated by torches, creating coatings. Monitoring sensors collect process data which are combined with ex situ characterization data.
Lila Randriamananjara, Vincent Rat, Quentin Dubreuil, Patrice Valorge, Simon Goutier, Alain Denoirjean, Olivier Messe, Céline Ruelle, Jean‐Philippe Poli   +8 more
wiley   +1 more source

Mitochondria‐Targeted Nanotherapies in Aging Neurodegenerative Disorders: Emerging Prospects and Clinical Potential

Advanced Healthcare Materials, EarlyView.
Mitochondria‐targeted nanotherapies emerge as a promising strategy for combating aging‐associated neurodegenerative disorders (NDs) by restoring mitochondrial function, reducing oxidative stress, and improving neuronal survival. Recent advances in nanotechnology, therapeutic delivery, and translational research are highlighted, providing insights into ...
Dnyandev G. Gadhave, Ashish B. Jadhav, Nitin B. Waghamode, Shubham Khot, Rajiya Khan, Ravi Hole, Shankar M. Dhobale, Manoj Aswar, Keshav Raj Paudel   +8 more
wiley   +1 more source