Results 221 to 230 of about 105,600 (307)

Multidisciplinary Strategies for Targeting Tumor Dormancy in Breast Cancer Therapeutics: Hallmarks, Mechanism, and Approaches

iMetaMed, EarlyView.
Clinical phases and classification of breast tumor dormancy. Tumor dormancy is described as the period after treatment until residual tumor cells become detectable as relapsing disease in clinic. During the period of clinical tumor dormancy, tumor mass dormancy and cellular dormancy may coexist.
Shu Chen, Hui Chen, Vijaya Raghavan, Jing Huang, Jin Wang   +4 more
wiley   +1 more source

Enhancing start-up and torque in Darrieus VAWTs through a novel plain gurney flap design. [PDF]

Sci Rep
Eltayeb W, Somlal J, SirElkhatim M, Yedukondalu G, Srinath A.   +4 more
europepmc   +1 more source

The T‐Cell Response Mechanism in Human Papillomavirus‐Associated Cervical Cancer and New Strategies for Immunotherapy

iNew Medicine, EarlyView.
ABSTRACT Human papillomavirus (HPV) is a double‐stranded DNA virus that infects human skin and mucosal tissues exclusively. The German scientist Harald zur Hausen was awarded the 2008 Nobel Prize in Physiology or Medicine for his discovery of the link between HPV infection and cervical cancer.
Fang Zhu, Farah Nazir, Ying Zhou, Yuhua Shang, Hongliang He, Tengchuan Jin   +5 more
wiley   +1 more source

Metabolic and oxidative mechanisms underlying flavor differences in yak meat across seasonal grazing-housing regimes: Evidence from integrated foodomics. [PDF]

Food Chem X
Wang Z, Shi S, Yu H, Sha Y, He C, Dai R, Zhou X, Bai Y, Cao W.   +8 more
europepmc   +1 more source

SUMOylation regulates tumorigenesis and progression: Molecular mechanisms and therapeutic applications

Interdisciplinary Medicine, EarlyView.
SUMOylation, a dynamic post‐translational modification, acts as a master regulator at the heart of tumor malignancy. Our work delineates how the SUMOylation cycle—mediated by E1/E2/E3 enzymes and reversed by SENPs—orchestrates multiple hallmarks of cancer. The central pathway converges on three critical pathological axes: 1.
Yimao Wu, Zichang Chen, Yinting Hu, Gokhan Zengin, Qian Zhang, Meng‐Yao Li, Wenlong Sun   +6 more
wiley   +1 more source

Impact of double split slot geometry on aerodynamic performance of modified airfoil for wind turbine blades. [PDF]

Sci Rep
Sarkar D, Sengupta AR, Paramasivam P, Bora BJ, Lakshmaiya N, Kalita P, Ayanie AG, Kanti PK.   +7 more
europepmc   +1 more source

Targeting eIF5A combats breast cancer progression by ClpP‐dependent mitochondrial oxidative stress

Interdisciplinary Medicine, EarlyView.
This study identified the eIF5A‐ClpP axis as a key driver of breast cancer progression. Targeting eIF5A suppresses tumor growth by inducing ClpP‐dependent mitochondrial oxidative stress, revealing a novel therapeutic vulnerability. Abstract Breast cancer (BC) poses a persistent global health challenge, necessitating new therapeutic targets.
Jinmei Zhu, Baoyuan Tang, Bei Xie, Haohua Deng, Haitang Yang, Lei Ma, Ziqing Zhang, Yicheng Ma, Xingyuan Ma, Shuaiyang Wang, Jing Li, Lei Zhao, Wengui Shi, Linjing Li   +13 more
wiley   +1 more source

Experimental Characterization of the Hydrodynamic Interactions between a Freely Rising Bubble and a Settling Particle. [PDF]

Langmuir
Outokesh M, Saeedipour M, Hlawitschka MW.   +2 more
europepmc   +1 more source

Perfectionism and School Non‐Attendance Reasons in Adolescents: A Latent Profile Analysis

Journal of Adolescence, EarlyView.
ABSTRACT Introduction Limited prior knowledge exists regarding perfectionism and other relevant educational variables, such as the wide spectrum of School Attendance Problems. However, perfectionism has been related to somatic complaints and symptoms, school burnout, and negative emotionality. Therefore, this study analyzes the association between this
Andrea Fuster, María Vicent, María Pérez‐Marco, Carolina Gonzálvez   +3 more
wiley   +1 more source