Results 51 to 60 of about 3,143,598 (238)

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

The Dynamics of Static Stall [PDF]

, 2011
The dynamic process of flow separation on a stationary airfoil in a uniform flow was investigated experimentally by means of time-resolved measurements of the velocity field and the airfoil's surface pressure distribution. The unsteady movement of the separation point, the growth of the separated region, and surface pressure fluctuations were examined ...
Mulleners, Karen, Le Pape, Arnaud, Heine, Benjamin, Raffel, Markus   +3 more
openaire   +3 more sources

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Numerical Study on Azimuthal Partition Combined Plasma Control for Rotor Airfoil Deep Dynamic Stall at High Advance Ratio

Aerospace
To address the challenge of effectively suppressing deep dynamic stall on the retreating side of rotor blades at high advance ratios, an azimuthal-zone plasma combined control strategy is proposed.
Weihong Kong, Peng Zhang, Tianxiang Wang
doaj   +1 more source

Large eddy simulation of dynamic stall over an airfoil and its control with plasma actuator

AIP Advances, 2023
The purpose of this study is to investigate deep dynamic stall over a pitching National Advisory Committee for Aeronautics 0015 airfoil and its control with an alternating current dielectric barrier discharge (AC-DBD) plasma actuator by means of large ...
Hengyang Zhang, Haocheng Yu, Ao Zhang, Jianguo Zheng   +3 more
doaj   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Numerical Investigation of a Dynamic Stall on a Single Rotating Blade

Aerospace, 2021
Dynamic stall is a phenomenon on the retreating blade of a helicopter which can lead to excessive control loads. In order to understand dynamic stall and fill the gap between the investigations on pitching wings and full helicopter rotor blades, a ...
Yin Ruan, Manfred Hajek
doaj   +1 more source

Mitochondrial translation and coordinated cytosolic translation in metabolic homeostasis and disease

FEBS Letters, EarlyView.
Mitochondrial function depends on coordinated protein production from the nuclear and mitochondrial genomes. This review highlights how cytosolic and mitochondrial translation, mRNA localization, protein import, and respiratory complex assembly are integrated to maintain mitochondrial proteostasis and function.
Boseon Kim, Thi Thanh Mai Tran, Nakyung Kang, Min‐Woo Lee, Mihye Lee   +4 more
wiley   +1 more source

Dynamic Stall Characteristics of Thick Wind Turbine Airfoils

Wind Energy
This paper studies the dynamic stall characteristics of thick flatback and nonflatback wind turbine airfoils. Two airfoils with a maximum thickness of 35% were studied, with trailing edge thicknesses of 2% and 10%, respectively.
Mehdi Doosttalab, Carlos Simao Ferreira, Daniele Ragni, Wei Yu, Christof Rautmann   +4 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source