Results 91 to 100 of about 2,947,979 (285)

Aberrant GRP78 Phase Transition Sustains Endothelial IRE1α Signaling and Drives Blood–Brain Barrier Failure in Cerebral Amyloid Angiopathy

Advanced Science, EarlyView.
Vascular Aβ40 corrupts GRP78 phase behavior in brain endothelial cells, sustaining IRE1α–TRAF2–JNK signaling and driving apoptosis, tight junction loss, and blood–brain barrier failure in cerebral amyloid angiopathy. Pharmacological IRE1α inhibition restores vascular integrity, reduces leakage, and improves functional outcomes, revealing a targetable ...
Honglin Zheng, Qiang Li, Haiyang Luo, Yapei Yuan, Na Zhang, Yongting Lu, Suying Duan, Jieshi Zhong, Hang Zhang, Chenyang Liu, Yaochong Zhang, Wenzhuo Zhao, Yaxuan Song, Tuo Wang, Si Yan, Yapeng Li, Han Liu, Yuan Gao, Zongping Xia, Yuming Xu   +19 more
wiley   +1 more source

Dynamic stall reattachment revisited

Journal of Fluid Mechanics
Dynamic stall on aerofoils is an undesirable and potentially dangerous phenomenon. The motto for aerodynamic systems with unsteadily moving wings, such as helicopters or wind turbines, is that prevention beats recovery. In case prevention fails or is not feasible, we need to know when recovery starts, how long it takes, and how we can improve it.
Rezapour, Sahar, Mulleners, Karen
openaire   +2 more sources

Pitching Airfoil Boundary Layer Investigations [PDF]

, 2006
The present paper describes an experiment performed in a transonic wind tunnel facility where a new test section has been developed especially for the investigation of the unsteady flow above oscillating airfoils under dynamic stall conditions.
Richter, Kai, Geißler, Wolfgang, Richard, Hugues, Bosbach, Johannes, Raffel, Markus   +4 more
core  

Agent‐Based Simulations of Lung Tumor Evolution Suggest That Ongoing Cell Competition Drives Realistic Clonal Expansions

Advanced Science, EarlyView.
Computational simulations of tumor evolution are increasingly used to infer the rules underlying cancer growth, with the goal of one day recommending tailored treatments. Here we show that the properties of lung cancer sequencing data are best replicated by a model which assumes that cells compete both to proliferate and survive. ABSTRACT Computational
Helena Coggan, James R. M. Black, Carlos Martínez‐Ruiz, Kristiana Grigoriadis, Jasmin Fisher, Nicholas McGranahan   +5 more
wiley   +1 more source

Effects of surface heat transfer on the dynamic stall performance of a pitching airfoil in turbulent flow

International Journal of Thermofluids
The dynamic stall phenomenon has been extensively studied in literature. Despite various innovative interventions focused on understanding its behavior, there are few efforts to study the influence of heat transfer on the dynamic stall performance of ...
Abbas Dorri, Masoud Darbandi
doaj   +1 more source

Experimental Investigation Of Air Jets To Control Shock-Induced Dynamic Stall

, 2013
This paper shows experimental results for dynamic stall control on a dynamically pitching OA209 airfoil at Mach 0.5, with Re=1.9×106 and Re=0.85×106. The control was by supersonic constant blowing on the suction side of the airfoil.
Richter, Kai, Neuhaus, Dietmar, Gardner, Anthony Donald, Mai, Holger   +3 more
core   +1 more source

Soft, Multi‐Wavelength Photoplethysmography Enables Reliable Neonatal Blood Pressure Monitoring Via Error Stratification

Advanced Science, EarlyView.
A soft hybrid multi‐wavelength PPG wearable acquires neonatal signals. Synchronized PPG and invasive ABP data are segmented into fixed windows. A 1D‐EfficientNet model predicts segment‐level SBP and DBP. Model performance is examined with retrospective subgroup analysis across acquisition conditions.
Wenqi Shi, Lanlan Mi, Jiarong Chen, Biao Liu, Min Wang, Zisheng Dai, Bin Liu, Ruize Gao, Yunfeng Lin, Weiwei Guo, Guoxing Wang, Wenyi Luo, Cheng Chen   +12 more
wiley   +1 more source

Stochastic Entanglement of Deterministic Origami Tentacles For Robust Robotic Grasping

Advanced Science, EarlyView.
This study introduces an origami tentacle gripper to robustly grasp objects‐in air, underwater, and even in orbital space‐by exploiting a synergy between local, deterministic deformation programming and global, stochastic entanglements. A single origami tentacle can be designed to coil with a simple tendon pull.
Alec Boron, Bokun Zheng, Ziyang Zhou, Noel Naughton, Suyi Li   +4 more
wiley   +1 more source

Sensitivity of Dynamic Stall Models to Dynamic Excitation on Large Flexible Wind Turbine Blades in Edgewise Vibrations

Energies
Present studies are specifically aimed at investigating the sensitivity of different dynamic stall models when exposed to various excitation frequencies. The investigations are targeted at blade edgewise vibrations.
Galih Bangga
doaj   +1 more source

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source