Results 91 to 100 of about 2,947,910 (287)

PolyG Fibrils Coalesce Into Nuclear Ribbons That Engage Proteostasis Machinery in Neuronal Intranuclear Inclusion Disease

Advanced Science, EarlyView.
In NIID, expanded NOTCH2NLC repeats give rise to nuclear polyG inclusions. Tracer‐guided in situ cryo‐electron tomography enables cross‐scale structural analysis from mouse brain to native neuronal nuclei, revealing dense‐core/peripheral‐halo inclusions built from compact polyG ribbons.
Hui Dong, Yongcheng Pan, Zhiyao Tang, Yuxuan Yao, Guicong Zhang, Junpu Wang, Haonan Xiao, Yun Tian, Beisha Tang, Dan Li, Qiang Guo, Ruijun Tian, Qiong Liu, Cong Liu   +13 more
wiley   +1 more source

Dynamic stall reattachment revisited

Journal of Fluid Mechanics
Dynamic stall on aerofoils is an undesirable and potentially dangerous phenomenon. The motto for aerodynamic systems with unsteadily moving wings, such as helicopters or wind turbines, is that prevention beats recovery. In case prevention fails or is not feasible, we need to know when recovery starts, how long it takes, and how we can improve it.
Rezapour, Sahar, Mulleners, Karen
openaire   +2 more sources

Pitching Airfoil Boundary Layer Investigations [PDF]

, 2006
The present paper describes an experiment performed in a transonic wind tunnel facility where a new test section has been developed especially for the investigation of the unsteady flow above oscillating airfoils under dynamic stall conditions.
Richter, Kai, Geißler, Wolfgang, Richard, Hugues, Bosbach, Johannes, Raffel, Markus   +4 more
core  

A Universal Protein Ladder for Standardization of Diverse FRET Assays

Advanced Science, EarlyView.
Translating FRET measurements from in vitro to intracellular environments requires universal benchmarks. We present a modular protein ladder using TPR motifs to harmonize data across diverse platforms. This predictable calibration curve bridges single molecule FRET measurements, with cell based measurements including FLIM‐FRET.
Evelyn R. Smith, Katie L. Gelder, Lewis Hunter‐Craig, Daniel A. Bose, Timothy D. Craggs, Alison E. Twelvetrees   +5 more
wiley   +1 more source

Sensitivity of Dynamic Stall Models to Dynamic Excitation on Large Flexible Wind Turbine Blades in Edgewise Vibrations

Energies
Present studies are specifically aimed at investigating the sensitivity of different dynamic stall models when exposed to various excitation frequencies. The investigations are targeted at blade edgewise vibrations.
Galih Bangga
doaj   +1 more source

Experimental Investigation Of Air Jets To Control Shock-Induced Dynamic Stall

, 2013
This paper shows experimental results for dynamic stall control on a dynamically pitching OA209 airfoil at Mach 0.5, with Re=1.9×106 and Re=0.85×106. The control was by supersonic constant blowing on the suction side of the airfoil.
Richter, Kai, Neuhaus, Dietmar, Gardner, Anthony Donald, Mai, Holger   +3 more
core   +1 more source

Aberrant GRP78 Phase Transition Sustains Endothelial IRE1α Signaling and Drives Blood–Brain Barrier Failure in Cerebral Amyloid Angiopathy

Advanced Science, EarlyView.
Vascular Aβ40 corrupts GRP78 phase behavior in brain endothelial cells, sustaining IRE1α–TRAF2–JNK signaling and driving apoptosis, tight junction loss, and blood–brain barrier failure in cerebral amyloid angiopathy. Pharmacological IRE1α inhibition restores vascular integrity, reduces leakage, and improves functional outcomes, revealing a targetable ...
Honglin Zheng, Qiang Li, Haiyang Luo, Yapei Yuan, Na Zhang, Yongting Lu, Suying Duan, Jieshi Zhong, Hang Zhang, Chenyang Liu, Yaochong Zhang, Wenzhuo Zhao, Yaxuan Song, Tuo Wang, Si Yan, Yapeng Li, Han Liu, Yuan Gao, Zongping Xia, Yuming Xu   +19 more
wiley   +1 more source

Effects of surface heat transfer on the dynamic stall performance of a pitching airfoil in turbulent flow

International Journal of Thermofluids
The dynamic stall phenomenon has been extensively studied in literature. Despite various innovative interventions focused on understanding its behavior, there are few efforts to study the influence of heat transfer on the dynamic stall performance of ...
Abbas Dorri, Masoud Darbandi
doaj   +1 more source

Agent‐Based Simulations of Lung Tumor Evolution Suggest That Ongoing Cell Competition Drives Realistic Clonal Expansions

Advanced Science, EarlyView.
Computational simulations of tumor evolution are increasingly used to infer the rules underlying cancer growth, with the goal of one day recommending tailored treatments. Here we show that the properties of lung cancer sequencing data are best replicated by a model which assumes that cells compete both to proliferate and survive. ABSTRACT Computational
Helena Coggan, James R. M. Black, Carlos Martínez‐Ruiz, Kristiana Grigoriadis, Jasmin Fisher, Nicholas McGranahan   +5 more
wiley   +1 more source

Unsteady Aerodynamics of Delta Kites for Airborne Wind Energy Under Dynamic Stall Conditions

Wind Energy
Three unsteady aerodynamic tools at different levels of fidelity and computational cost were used to investigate the unsteady aerodynamic behavior of a delta kite applied to airborne wind energy.
I. Castro‐Fernández, R. Cavallaro, R. Schmehl, G. Sánchez‐Arriaga   +3 more
doaj   +1 more source