Results 91 to 100 of about 3,143,598 (238)

Granzyme B PET Imaging Reveals Lgmn+ Macrophage‐Mediated Immune Evasion and Guides Immunotherapy in EGFR‐TKI‐Resistant NSCLC

Advanced Science, EarlyView.
Graphical illustration of 68Ga‐GZB PET/CT imaging reveals immune dynamics post‐EGFR‐TKI resistance in NSCLC; Lgmn+ macrophages‐derived Lgmn‐containing extracellular vesicles inhibit glycolysis, induce CD8+ T cell exhaustion, and targeting Lgmn restores immunotherapy sensitivity.
Dongliang Wang, Wenqin Luo, Qiufang Liu, Wenxuan Tang, Bin Zhu, Jiwei Chen, Qian Zhou, Shuang Tang, Xiaoping Xu, Shaoli Song   +9 more
wiley   +1 more source

Stimulation of OGG1 Enhances Oxidative DNA Damage Repair and Protects Against Acute Liver Failure by Acetaminophen

Advanced Science, EarlyView.
Chemical switching of OGG1 by CMM‐98 accelerates oxidative DNA damage repair and enhances hepatocyte resilience during acetaminophen‐induced acute liver injury. By promoting efficient processing of OGG1‐generated repair intermediates, CMM‐98 reduces oxidative damage, preserves cellular integrity, and protects against acute liver failure, identifying ...
Zhenjun Zhao, Rahul Upadhyay, Alice Eddershaw, Chenchen Wang, Yudong Zhao, Olov Wallner, Jinhye Ryu, Nayere Taebnia, Heather Gildie, Emma Scaletti‐Hutchinson, Jonathan R. Davies, Nicole Ziegler, Andreas Krämer, Samantha C. Robinson, Marek Varga, Karolina Singerova, Zuzanna Szaruga, Elisée Wiita, İrşil Güneş, Sheila S. David, Stefan Knapp, Aimo Kannt, Miguel de Vega, Pål Stenmark, Volker M Lauschke, Maurice Michel   +25 more
wiley   +1 more source

Dynamic stall reattachment revisited

Journal of Fluid Mechanics
Dynamic stall on aerofoils is an undesirable and potentially dangerous phenomenon. The motto for aerodynamic systems with unsteadily moving wings, such as helicopters or wind turbines, is that prevention beats recovery. In case prevention fails or is not feasible, we need to know when recovery starts, how long it takes, and how we can improve it.
Rezapour, Sahar, Mulleners, Karen
openaire   +2 more sources

Pitching Airfoil Boundary Layer Investigations [PDF]

, 2006
The present paper describes an experiment performed in a transonic wind tunnel facility where a new test section has been developed especially for the investigation of the unsteady flow above oscillating airfoils under dynamic stall conditions.
Richter, Kai, Geißler, Wolfgang, Richard, Hugues, Bosbach, Johannes, Raffel, Markus   +4 more
core  

Constrained predictive control of ship fin stabilizers to prevent dynamic stall

, 2008
In moderate to high sea states, the effectiveness of ship fin stabilizers can severely deteriorate due to nonlinear effects arising from unsteady hydrodynamic characteristics of the fins: dynamic stall.
Goodwin, Graham C., Perez, Tristan
core   +1 more source

In Situ Photo‑Crosslinked Functional Bilayer Hydrogel Modulates Local Microenvironment and Remyelination After Optic Nerve Injury

Advanced Science, EarlyView.
A blue‐light‐crosslinked bilayer hydrogel was developed for local optic nerve repair. The adhesive GM‐Odex outer layer seals and anchors the lesion, while the non‐adhesive GM‐imid inner layer releases MPDA‐Cle without obstructing CSF flow. This system modulates oxidative and inflammatory microenvironments, supports oligodendrocyte differentiation and ...
Tonghe Pan, Yate Huang, Junhao Zhang, Shudong Tian, Zhixing Li, Xuanwen Li, Yanchen Zhang, Dongmei Wang, Sihao Ye, Ming Jin, Neng Ling, Wentao Yan, Kaihui Nan, Wencan Wu   +13 more
wiley   +1 more source

SEC Mediates m6A Deposition and Transcription Pause Release to Drive Cell Identity Transition

Advanced Science, EarlyView.
The SEC promotes cell identity transitions by facilitating transcription pause release at key identity‐associated genes, including Klf4 and Myc during iPSC reprogramming and Nes and Tubb3 during ESC‐to‐neuroectodermal differentiation. During early iPSC reprogramming, this function additionally involves cooperation with METTL3‐associated m6A regulation.
Zhijing Zhang, Jingyi Xu, Yonghong Wu, Yitong Qu, Xinglin Hu, Yuchen Sun, Yanshuang Wu, Zhonghua Liu, Jiaqiang Wang, Lei Lei   +9 more
wiley   +1 more source

The phenomenon of dynamic stall [PDF]

, 1981
The general features of dynamic stall on oscillating airfoils are explained in terms of the vortex shedding phenomenon, and the important differences between static stall, light dynamic stall, and deep stall are described.
Mccroskey, W. J.
core  

Unsteady Aerodynamics of Delta Kites for Airborne Wind Energy Under Dynamic Stall Conditions

Wind Energy
Three unsteady aerodynamic tools at different levels of fidelity and computational cost were used to investigate the unsteady aerodynamic behavior of a delta kite applied to airborne wind energy.
I. Castro‐Fernández, R. Cavallaro, R. Schmehl, G. Sánchez‐Arriaga   +3 more
doaj   +1 more source

Effects of surface heat transfer on the dynamic stall performance of a pitching airfoil in turbulent flow

International Journal of Thermofluids
The dynamic stall phenomenon has been extensively studied in literature. Despite various innovative interventions focused on understanding its behavior, there are few efforts to study the influence of heat transfer on the dynamic stall performance of ...
Abbas Dorri, Masoud Darbandi
doaj   +1 more source