Results 91 to 100 of about 16,890,236 (293)

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Machine learning classifier-based dynamic surrogate model for structural reliability analysis

, 2023
The performance functions of large-scale complex structures are often implicit and nonlinear, which leads to problems such as high computational costs and low computational accuracy in reliability calculation.
Ying Zhao (16546), Weizhe Sun (9655738), Guoshao Su (16029201)   +2 more
core   +1 more source

Machine tool FEM model correction assisted by dynamic evolution sequence

Scientific Reports
In the simulation analysis of large-scale industrial instruments such as machine tools, in order to ensure simulation accuracy, model parameter correction is necessary. This research presents a machine tool model correction method assisted by the dynamic
Weihao Lin, Peng Zhong, Xindi Wei, Li Zhu, Xuanlong Wu   +4 more
doaj   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Atmospheric Chemistry Surrogate Modeling With Sparse Identification of Nonlinear Dynamics

Journal of Geophysical Research: Machine Learning and Computation
AbstractModeling atmospheric chemistry is computationally expensive and limits the widespread use of chemical transport models. This computational cost arises from solving high‐dimensional systems of stiff differential equations. Previous work has demonstrated the promise of machine learning (ML) to accelerate air quality model simulations but has ...
Xiaokai Yang, Lin Guo, Zhonghua Zheng, Nicole Riemer, Christopher W. Tessum   +4 more
openaire   +2 more sources

Reservoir-based surrogate modeling of dynamic user equilibrium

Transportation Research Procedia, 2019
Abstract This paper proposes a new dynamic user equilibrium (DUE) traffic assignment model using reservoir-based network reduction techniques and surrogate dynamic network loading models. A traffic network is decomposed into a reservoir structure, and the DUE problem is formulated as a variational inequality, with an embedded surrogate model for the ...
Qian Ge, Daisuke Fukuda, Ke Han, Wenjing Song   +3 more
openaire   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Dynamic response improvement for multi-terminal DC system with AI-designed adaptive dynamic reference control

International Journal of Electrical Power & Energy Systems
The significant penetration of renewable energy sources (RES) makes the AC/DC hybrid system a typical low-inertia and poor-damping system. The multi-terminal direct current system (MTDC) is critical in connecting multiple AC systems and transferring bulk
Qifan Yang, Gang Lin, Xin Jin, Bin Zhang, Ningyi Dai   +4 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source