Results 111 to 120 of about 16,890,236 (293)
Promet (Zagreb), 2018 This paper presents a procedure for analysing safety and operational improvements made possible by converting traffic circles to modern roundabouts. An Italian case study is presented for alternative layouts under various traffic demand scenarios. In the
Antonio Pratelli +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
CoRRComputational models provide crucial insights into complex biological processes such as cancer evolution, but their mechanistic nature often makes them nonlinear and parameter-rich, complicating calibration. We systematically evaluate parameter probability distributions in cell migration models using Bayesian calibration across four complementary ...
Christina Schenk +2 more
openaire +3 more sources
Applied SciencesIn the context of expensive constraint multi-objective problems, it is evident that the feasible domain shapes and sizes of different problems vary considerably. The difficulty in finding optimal solutions presents a significant challenge in ensuring the
Yu Sun, Yifan Ma, Bei Hua
doaj +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Applied SciencesLiquid-lubricated spherical spiral-groove hydrodynamic bearings (SSGB) sustain composite loads under high-speed conditions. This study establishes a numerical framework for SSGB lubrication and proposes a physics-guided hybrid surrogate model to ...
Huabiao Zhang +5 more
doaj +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Surrogate Models for Investigating Dynamic Security Regions of Renewables-Dominated Grids
2024 IEEE PES Innovative Smart Grid Technologies Europe (ISGT EUROPE)Conventional grid operational planning usually entails dynamic security assessment performed by running time-domain simulations. This requires detailed modelling and is computationally burdensome. An alternative is to use a machine learning approach as a lightweight surrogate to evaluate stability for a set of operational inputs.
Lu, Junyi +5 more
openaire +3 more sources
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source