Results 121 to 130 of about 16,890,236 (293)

Folder 6: Model engine data sheets and operating instructions, J - N, ca. 1960, 1972, 1988

, 1960
Instructions, illustrations, and parts price list for a Dynamic Models, INC. Johnson Engines.
Dynamic Models, Inc.
core  

Bayesian optimization of underground railway tunnels using a surrogate model

Data-Centric Engineering
The assessment of soil–structure interaction (SSI) under dynamic loading conditions remains a challenging task due to the complexities of modeling this system and the interplay of SSI effects, which is also characterized by uncertainties across varying ...
Hassan Liravi, Hoang-Giang Bui, Sakdirat Kaewunruen, Aires Colaço, Jelena Ninić   +4 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

AI-Based Surrogate Models for Multibody Dynamics Systems

Journal of Physics: Conference Series
Abstract Advancements in computer sciences and technology allow for implementation of detailed numerical models of a system such as the Finite Element (FE) or Multibody Dynamics (MBD) models. Complex mechanical systems can easily be modelled in detail, yielding accurate results.
J Koutsoupakis, D Giagopoulos
openaire   +1 more source

A GRU-KAN Surrogate Model with Genetic Algorithm Uniform Sampling for Active Magnetic Bearings–Rotor Critical Speed Prediction

Sensors
With the development of active magnetic bearings (AMBs) toward higher speeds, understanding high-speed rotor dynamics has become a crucial focus in AMB research.
Jiahang Cui, Jianghong Li, Feichao Cai, Zhenmin Zhao, Yuxi Liu   +4 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

asMODiTS: An application of surrogate models to optimize Time Series symbolic discretization through archive-based training set update strategy

MethodsX
The enhanced multi-objective symbolic discretization for time series (eMODiTS) uses an evolutionary process to identify the appropriate discretization scheme in the Time Series Classification (TSC) task.
Aldo Márquez-Grajales, Efrén Mezura-Montes, Héctor-Gabriel Acosta-Mesa, Fernando Salas-Martínez   +3 more
doaj   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Surrogate Model for In-Medium Similarity Renormalization Group Method Using Dynamic Mode Decomposition

Particles
I propose a data-driven surrogate model for the In-Medium Similarity Renormalization Group (IMSRG) method using Dynamic Mode Decomposition (DMD). First, the Magnus formulation of the IMSRG is leveraged to represent the unitary transformation of many-body
Sota Yoshida
doaj   +1 more source