Results 61 to 70 of about 204,378 (285)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Research on surrogate models and optimization of equipment dynamics for complex systems

AIP Advances
In this paper, we use tracked vehicles as an example to study complex systems and surrogate model building method. Due to the high cost and long development cycle associated with the traditional development approach, involving static design and ...
Haigen Yang, Xu Bai, Chao Wang
doaj   +1 more source

Design optimization of a nuclear main steam safety valve based on an E-AHF ensemble surrogate model

Nuclear Engineering and Technology, 2022
Main steam safety valves are commonly used in nuclear power plants to provide final protections from overpressure events. Blowdown and dynamic stability are two critical characteristics of safety valves.
Chaoyong Zong, Maolin Shi, Qingye Li, Fuwen Liu, Weihao Zhou, Xueguan Song   +5 more
doaj   +1 more source

Surrogate articular contact models for computationally efficient multibody dynamic simulations

Medical Engineering & Physics, 2010
Contact occurs in a wide variety of multibody dynamic systems, including the human musculoskeletal system. However, sensitivity and optimization studies of such systems have been limited by the high computational cost of repeated contact analyses. This study presents a novel surrogate modeling approach for performing computationally efficient three ...
Department of Mechanical, Aerospace Engineering, University of Florida, Gainesville, FL, USA ( host institution ), Lin, Yi-Chung ( author ), Haftka, Raphael T. ( author ), Queipo, Nestor V. ( author ), Fregly, Benjamin J. ( author )   +5 more
openaire   +3 more sources

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Symplectic neural surrogate models for beam dynamics

Journal of Physics: Conference Series
Abstract Development of robust machine-learning (ML) based surrogates for particle accelerators can significantly benefit the modeling, design, optimization, monitoring and control of such accelerators. It is desirable that the surrogate models embed fundamental physical constraints to the interaction and dynamics of the beams, for which
Burby,Joshua, Batygin,Yuri, Beznosov,Oleksii, Kwan,Thomas, Huang,Chengkun, Rakotoarivelo,Hoby, Kim,Anastasiia, Kurennoy,Sergey, Tang,Qi   +8 more
openaire   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Online learning supported surrogate-based flowsheet model maintenance

Digital Chemical Engineering
Surrogate-based flowsheet model calibration is a critical extension of using flowsheet models in Digital Twin (DT) systems. However, maintaining accurate surrogates over time is increasingly challenging, especially when models are deployed in real-time ...
Balázs Palotai, Gábor Kis, Tibor Chován, Ágnes Bárkányi   +3 more
doaj   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Decomposition-Assisted Computational Technique Based on Surrogate Modeling for Real-Time Simulations

Complexity, 2017
The development of complex simulation systems is extremely costly as it requires high computational capability and expensive hardware. As cost is one of the main issues in developing simulation components, achieving real-time simulation is challenging ...
Nariman Fouladinejad, Nima Fouladinejad, Mohamad Kasim Abdul Jalil, Jamaludin Mohd Taib   +3 more
doaj   +1 more source