Results 81 to 90 of about 204,378 (285)

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Design of Dynamic Systems Using Surrogate Models of Derivative Functions [PDF]

Journal of Mechanical Design, 2017
Optimization of dynamic systems often requires system simulation. Several important classes of dynamic system models have computationally expensive time derivative functions, resulting in simulations that are significantly slower than real time. This makes design optimization based on these models impractical.
Anand P. Deshmukh, James T. Allison
openaire   +1 more source

A Gaussian Mixture MRF for Model-Based Iterative Reconstruction with Applications to Low-Dose X-ray CT

, 2016
Markov random fields (MRFs) have been widely used as prior models in various inverse problems such as tomographic reconstruction. While MRFs provide a simple and often effective way to model the spatial dependencies in images, they suffer from the fact ...
Bouman, Charles A., Pal, Debashish, Sauer, Ken D., Thibault, Jean-Baptiste, Ye, Dong Hye, Zhang, Ruoqiao   +5 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Design method of high-flux lead-bismuth cooled reactor neutron flux maximization based on BP neural network

He jishu
BackgroundThe development of high-throughput reactors is of great significance for supporting the development of nuclear science and technology, improving the efficiency of nuclear energy utilization, meeting the needs of radioactive isotope production ...
WANG Tong, LIU Zijing, ZHAO Pengcheng, XIAO Yingjie   +3 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Dynamic PRA: an Overview of New Algorithms to Generate, Analyze and Visualize Data [PDF]

, 2013
State of the art PRA methods, i.e. Dynamic PRA (DPRA) methodologies, largely employ system simulator codes to accurately model system dynamics. Typically, these system simulator codes (e.g., RELAP5 ) are coupled with other codes (e.g., ADAPT, RAVEN
A. Yilmaz, ALFONSI, ANDREA, B. Wang, C. Rabiti, C. Smith, D. Maljovec, D. Mandelli, P. T. Bremer, R. Youngblood, T. Aldemir, V. Pascucci   +10 more
core  

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Dynamic Surrogate Model-Driven Multi-Objective Shape Optimization for Photovoltaic-Powered Underwater Vehicle

Journal of Marine Science and Engineering
In this study, a multi-objective shape optimization framework was established for photovoltaic-powered underwater vehicles (PUVs) to systematically investigate multidisciplinary coupled design methodologies.
Chenyu Wang, Likun Peng, Jiabao Chen, Wei Pan, Jia Chen, Huarui Wang   +5 more
doaj   +1 more source