Results 131 to 140 of about 158,447 (307)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Dynamic Tension Control System for Chain of Scraper Conveyor and Its Applicatio
Gong-kuang zidonghua, 2012 For problem of frequent faults of scraper and chain breakage caused by traditional artificial tension mode for chain of scraper conveyor, the paper introduced composition, working principle and operation mode of a dynamic tension control system for chain
CHEN Ju
doaj
Parametric Study on Dynamic Tension Behaviour of Offshore Pipeline for Deepwater S-lay Operation
E3S Web of Conferences, 2018 In recent years, higher demands for offshore pipeline design of deepwater installation are put forward. This paper mainly aims to investigate the influence of pipelay parameters on dynamic tension behaviour of deepwater S-lay pipeline to optimize the ...
Xu Pu +3 more
doaj +1 more source
Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis
Molecular Oncology, EarlyView.LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini +1 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
DYNAMIC RESPONSE CALCULATION OF ROD UNDER ECCENTRIC TENSION AND COMPRESSION LOADINGS
Jixie qiangdu, 2016 The bars under tension and compression loadings widely exist in the structural engineering applications,which are the important loaded elements. This is because of the existence of all kinds of installed errors,the bars under tension and compression ...
CHU JunLiang
doaj
Tensegrity space structures : static, kinematic and stability behaviour [PDF]
, 2011 This dissertation is an in depth study of the design and behaviour of tensegrity space structures. It deals with various aspects of these systems including form-finding and analysis.
Sulaiman, Muzzammil
core
Astrocyte heterogeneity in brain metastases
Molecular Oncology, EarlyView.Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver +2 more
wiley +1 more source
SEMI-ANALYTUCAL SOLUTION TO DYNAMIC ANALYSIS FOR PLOUGH SYSTEM
Jixie qiangdu, 2018 According to working features of plough system,three sections of visco-elastic dynamic model were established based on wave theory. The boundary conditions,joining conditions and initial condition of wave equation under stable running were determined ...
CHEN Hong Yue +4 more
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