Results 141 to 150 of about 1,139 (243)

Clinical Functional Assignment of TPMT and NUDT15 Alleles by the Clinical Pharmacogenetics Implementation Consortium Pharmacogene Curation Expert Panel

Clinical Pharmacology &Therapeutics, EarlyView.
The Clinical Pharmacogenetics Implementation Consortium (CPIC) TPMT/NUDT15 Pharmacogene Curation Expert Panel (PCEP) conducted a comprehensive review of clinical, laboratory, and computational evidence to determine the clinical function assignments for TPMT and NUDT15 star alleles.
Bailey M. Tibben, Maud Maillard, Victoria M. Pratt, Ann M. Moyer, Debbie M. Figueroa, Michelle Whirl‐Carrillo, Andrea Gaedigk, Gabriele Stocco, Matthias Schwab, Kelly E. Caudle, Jun J. Yang   +10 more
wiley   +1 more source

Deep patch-clamp recordings in awake mice from medial septal neurons during hippocampal sharp-wave ripples. [PDF]

Neuroreport
Samejima H, Sato Y, Ikegaya Y, Kashima T.   +3 more
europepmc   +1 more source

A Dynamic Business Modeling Approach to Port Sustainability: The Western Sicily Port Authority Case

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT Ports are critical nodes in global trade and economic development, yet they generate substantial environmental and social externalities—including greenhouse gas emissions, air, noise, and water pollution, and adverse impacts on host communities—that demand integrated and forward‐looking governance.
Martina Vivoli, Annalisa Tardino, Luca Lupi, Federico Cosenz   +3 more
wiley   +1 more source

A fusion deep Q-learning and particle swarm optimization algorithm for adaptive resource allocation in cloud computing circumstances. [PDF]

Sci Rep
Al-Jumaili AHA, Seno ME, Awad WK, Muniyandi RC, Hasan MK.   +4 more
europepmc   +1 more source

Modeling and monitoring injectivity evolution during cold CO2 injection with field evidence from aquistore carbon capture and storage operations

Deep Underground Science and Engineering, EarlyView.
This work integrates 5 years of field data from the Aquistore CCS project with a non‐isothermal THM modeling framework to explain how cold CO2 injection alters injectivity over time. The study shows that sustained cooling near the wellbore reduces effective stresses, promotes tensile micro‑cracking, and leads to semi‑reversible permeability enhancement
Alireza Rangriz Shokri, Stephen Talman, Erik Nickel, Rick Chalaturnyk   +3 more
wiley   +1 more source

Neural circuits and emotional processing in rapid eye movement sleep. [PDF]

Front Psychiatry
Chang LY, Wang YQ, Li Z, Zhang Y, Huang ZL, Yang SR.   +5 more
europepmc   +1 more source

Dynamic prediction of coal and gas outburst risk based on quantitative analysis of stress–energy evolution and adaptive correction

Deep Underground Science and Engineering, EarlyView.
This study quantitatively analyzed the spatiotemporal evolution of stress redistribution ahead of the working face by integrating coal seam distribution, tectonic stress anomalies, gas pressure, and mining‐induced disturbances. An R‐value criterion for coal and gas outburst (CGO) risk assessment was established based on energy principles.
Yingjie Zhao, Xueqiu He, Dazhao Song, Liming Qiu, Minggong Guo, Jie Liu, Qiang Liu, Yi Zhu   +7 more
wiley   +1 more source

Efficient energy consumption in hybrid cloud environment using adaptive backtracking virtual machine consolidation. [PDF]

Sci Rep
Manikandan S, Elakiya E, Rajheshwari KC, Sivakumar K.   +3 more
europepmc   +1 more source

A proteomic investigation of forebrain regeneration in the leopard gecko (Eublepharis macularius)

Developmental Dynamics, EarlyView.
Our investigation reveals ontogenetic, injury‐ and regeneration‐associated proteomic changes in the leopard gecko forebrain. Abstract Background The ability to replace lost or damaged neurons following an injury is termed reactive neurogenesis. Although reactive neurogenesis has been reported in several lizard species, the molecular mechanisms ...
Alexandra I. Noble, Samantha L. Payne, Matthew K. Vickaryous   +2 more
wiley   +1 more source

Tele-ICU platform model: point of care equipment telemetry and real-time remote critical assistance. [PDF]

Crit Care Sci
Cavalcante C, Cavalcante Neto PM, Guerra W, Rodrigues A, Martins A, Yokoyama TS, Oliveira PR, Amato MBP, Carvalho CRR.   +8 more
europepmc   +1 more source