Results 171 to 180 of about 1,090 (241)

Integrative Multi‐Omics Analysis Reveals Convergent Epigenome and Transcriptome Changes in Parkinson's Disease

open access: yesMovement Disorders, EarlyView.
Abstract Background The mechanisms that predispose dopaminergic neurons (DAN) to degeneration in Parkinson's disease (PD) are incompletely understood. Objective To perform an integrative multi‐omics reanalysis of single‐cell transcriptomic and epigenomic data to identify convergent alterations predisposing dopaminergic neurons to degeneration in ...
Mirco Macchi   +127 more
wiley   +1 more source

Smart load balancing in cloud computing: Integrating feature selection with advanced deep learning models. [PDF]

open access: yesPLoS One
Sanjalawe Y   +5 more
europepmc   +1 more source

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

open access: yesMedicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli   +5 more
wiley   +1 more source

Human In Vivo Validation of Frequency‐Dependent QTI

open access: yesMagnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose The aim of this work is to investigate if q‐space trajectory imaging (QTI) waveforms can be designed to probe QTI metrics at a single centroid frequency under realistic experimental conditions for in vivo human brain imaging. Methods Realistic diffusion encoding waveforms based on double‐rotation gradient waveform and magic‐angle ...
Svenja Niesen   +3 more
wiley   +1 more source

Correlating Pulmonary Hemodynamics With HP 129Xe Dissolved‐Phase MRSI in a Controlled Porcine Intervention Study

open access: yesMagnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose Pulmonary hypertension is related to a 1‐year mortality ranging from < 5% to > 20% in low‐ and high‐risk groups. Right heart catheterization is the diagnostic gold standard, associated with a 1.1% rate of severe adverse events, posing the need for a non‐invasive diagnostic tool.
Markus Phillip Andersen   +7 more
wiley   +1 more source

Review of the Progressing Role of Solar Photovoltaics in Energy Transition Scenarios Over Five Decades of 100% Renewable Energy Systems Research

open access: yesProgress in Photovoltaics: Research and Applications, EarlyView.
Over the last five decades, several milestones in energy system modelling enabled the progressing role of solar PV in the field of 100% renewable energy systems research. The key advancements are grouped into visionary scoping, advances in PV system applications, expanding economic insights, methodological advances and additional aspects. ABSTRACT Five
Christian Breyer   +5 more
wiley   +1 more source

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