Results 61 to 70 of about 1,514,651 (306)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Forecasting experiments of a dynamical–statistical model of the sea surface temperature anomaly field based on the improved self-memorization principle [PDF]

Ocean Science, 2018
With the objective of tackling the problem of inaccurate long-term El Niño–Southern Oscillation (ENSO) forecasts, this paper develops a new dynamical–statistical forecast model of the sea surface temperature anomaly (SSTA) field.
M. Hong, M. Hong, X. Chen, R. Zhang, R. Zhang, D. Wang, S. Shen, V. P. Singh   +7 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Influence of orientation degree of freedom on fission dynamics of higly excited nuclei

EPJ Web of Conferences, 2013
Four-dimensional dynamical model was developed and employed for study fission characteristics in a wide range of fissility parameter. The three collective shape coordinates plus the K coordinate, which is the spin of the nucleus with respect to the ...
Nadtochy P.N., Ryabov E.G., Gegechkori A.E., Anischenko Yu.A., Adeev G.D.   +4 more
doaj   +1 more source

Nonlinear dissipative systems dynamical characteristics determination based on linear-parametrical discrete model of amplitude-frequency characteristic

Vestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2008
Considering the mechanical system linear-parametrical discrete model of AFC with dissipative nonlinear forces in form of accidental difference equation, this work offers effective method of dynamical characteristics determination based on numeral ...
D. N. Popova
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Influence of Damping on the Dynamical Behavior of the Electrostatic Parallel-plate and Torsional Actuators with Intermolecular Forces

, 2007
The influence of damping on the dynamical behavior of the electrostaticparallel-plate and torsional actuators with the van der Waals (vdW) or Casimir force(torque) is presented. The values of the pull-in parameters and the number of theequilibrium points
Ya-Pu Zhao, Wen-Hui Lin, Zhao YP(赵亚溥), Zhao, YP (reprint author), Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech LNM, Beijing 100080, Peoples R China., Lin WH(林文慧)   +4 more
core   +2 more sources

Long-time dynamics of a random higher-order Kirchhoff model with variable coefficient rotational inertia

Results in Applied Mathematics
This paper delves into the stochastic asymptotic behavior of a non-autonomous stochastic higher-order Kirchhoff equation with variable coefficient rotational inertia.
Penghui Lv, Yuxiao Cun, Guoguang Lin
doaj   +1 more source

Bayesian Analysis of Coefficient Instability in Dynamic Regressions [PDF]

Econometrics, 2011
This paper deals with instability in regression coefficients. We propose a Bayesian regression model with time-varying coefficients (TVC) that allows to jointly estimate the degree of instability and the time-path of the coefficients. Thanks to the computational tractability of the model and to the fact that it is fully automatic, we are able to run ...
Emanuela Ciapanna, Marco Taboga
openaire   +5 more sources

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source