Results 51 to 60 of about 30,848 (265)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Results in Applied MathematicsThis paper delves into the stochastic asymptotic behavior of a non-autonomous stochastic higher-order Kirchhoff equation with variable coefficient rotational inertia.
Penghui Lv, Yuxiao Cun, Guoguang Lin
doaj +1 more source
Discrete Dynamics in Nature and Society, 2014 With the objective of tackling the problem of inaccurate long-term western pacific subtropical high (WPSH) forecasts, based on the concept of dynamical model reconstruction and improved self-memorization principle, a new dynamical forecasting model of ...
Mei Hong +5 more
doaj +1 more source
Influence of Dynamical Change of Edges on Clustering Coefficients [PDF]
Discrete Dynamics in Nature and Society, 2015 Clustering coefficient is a very important measurement in complex networks, and it describes the average ratio between the actual existent edges and probable existent edges in the neighbor of one vertex in a complex network. Besides, in a complex networks, the dynamic change of edges can trigger directly the evolution of network and further affect the ...
Yuhong Ruan, Anwei Li
openaire +3 more sources
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Bifurcation analysis and dynamics of a Lorenz –type dynamical system
پژوهشهای ریاضی, 2017 ./files/site1/files/0Abstract1.pdfIn this paper we consider a continues Lorenz – type dynamical system. Dynamical behaviors of this system such as computing equilibrium points, different bifurcation curves and computation of normal form coefficient of ...
Behnaz Rahmani +3 more
doaj
NUST Journal of Engineering Sciences, 2016 Non linearity is the complicated problem for the dynamic modeling parameters solutions. The frequency and damping along with wavelength and particularly bogie wavelength are the fundamental terms to analyze the proper running of the railway vehicle ...
Zulfiqar Ali Soomro
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source