Dynamical modeling of the H3K27 epigenetic landscape in mouse embryonic stem cells. [PDF]
PLoS Comput Biol, 2022 Newar K +4 more
europepmc +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Parameter Sensitivity and Experimental Validation for Fractional-Order Dynamical Modeling of Neurovascular Coupling. [PDF]
IEEE Open J Eng Med Biol, 2022 Belkhatir Z +3 more
europepmc +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
A computational network dynamical modeling for abnormal oscillation and deep brain stimulation control of obsessive-compulsive disorder. [PDF]
Cogn Neurodyn, 2023 Yin L, Han F, Yu Y, Wang Q.
europepmc +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
MODELING OF PLANT TISSUE GROWTH AND DEVELOPMENT WITH L-SYSTEMS
Вавиловский журнал генетики и селекции, 2014 An introduction to modeling of dynamical systems possessing dynamical structures with L-systems is given. Application of L systems is illustrated by models of plant tissue growth and control of state variable distribution in the growing tissue.
U. S. Zubairova +2 more
doaj
GraphVAMPNet, using graph neural networks and variational approach to Markov processes for dynamical modeling of biomolecules. [PDF]
J Chem Phys, 2022 Ghorbani M +3 more
europepmc +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Nonlinear dynamical modeling of neural activity using volterra series with GA-enhanced particle swarm optimization algorithm. [PDF]
Cogn Neurodyn, 2023 Chang S +6 more
europepmc +1 more source