Results 101 to 110 of about 58,720 (307)

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Dynamical systems, attractors, and neural circuits [version 1; referees: 3 approved]

F1000Research, 2016
Biology is the study of dynamical systems. Yet most of us working in biology have limited pedagogical training in the theory of dynamical systems, an unfortunate historical fact that can be remedied for future generations of life scientists.
Paul Miller
doaj   +1 more source

A Dynamic Model of Congestion

Bulletin of the Brazilian Mathematical Society, New Series
Abstract We revisit the classic problem of determining optimal routes in a graph for transporting two given distributions defined on its nodes, originally studied by Wardrop and Beckmann in the 1950s. The global congestion profile at any given time defines a dynamic metric on the graph, for which the routes must be geodesics.
Héctor A. Chang-Lara, Sergio D. Zapeta-Tzul   +1 more
openaire   +2 more sources

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Time-varying Normalizing Flow for Generative Modeling of Dynamical Signals

, 2022
We develop a time-varying normalizing flow (TVNF) for explicit generative modeling of dynamical signals. Being explicit, it can generate samples of dynamical signals, and compute the likelihood of a (given) dynamical signal sample. In the proposed model,
Anubhab Ghosh, Abdalmoaty, Mohamed,, Chatterjee, Saikat,, Aleix Espuna Fontcuberta, Saikat Chatterjee, Abdalmoaty, Mohamed R-H,, Fontcuberta, Aleix Espuna,, Ghosh, Anubhab,, Mohamed R.-H. Abdalmoaty   +8 more
core   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Towards a fluid-dynamic description of an entire heavy-ion collision: From the colliding nuclei to the quark-gluon plasma phase [PDF]

EPJ Web of Conferences
The fluid-dynamical modeling of a nuclear collision at high energy usually starts shortly after the collision. A major source of uncertainty comes from the detailed modeling of the initial state.
Kirchner Andreas, Capellino Federica, Grossi Eduardo, Floerchinger Stefan   +3 more
doaj   +1 more source

A Dynamic Model of Repositioning [PDF]

Marketing Science, 2018
Consumer preferences change through time and firms must adjust their product positioning for their products to continue to be appealing to consumers. These changes in product positioning require fixed investments such that firms reposition only occasionally. I construct a model that can include predictable and unpredictable consumer preference changes,
openaire   +3 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source