A computational network dynamical modeling for abnormal oscillation and deep brain stimulation control of obsessive-compulsive disorder. [PDF]
Cogn Neurodyn, 2023 Yin L, Han F, Yu Y, Wang Q.
europepmc +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
GraphVAMPNet, using graph neural networks and variational approach to Markov processes for dynamical modeling of biomolecules. [PDF]
J Chem Phys, 2022 Ghorbani M +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Modeling Tidal Disruptions with Dynamical Tides
The Astrophysical JournalTidal disruption events (TDEs) occur when stars pass close enough to supermassive black holes to be torn apart by tidal forces. Traditionally, these events are studied with computationally intensive hydrodynamical simulations. In this paper, we present a
Zihan Zhou +3 more
doaj +1 more source
Nonlinear dynamical modeling of neural activity using volterra series with GA-enhanced particle swarm optimization algorithm. [PDF]
Cogn Neurodyn, 2023 Chang S +6 more
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A Computational Theory of Dynamical Modeling in Scientific Reasoning
, 1997 The focus of this research is on dynamical modeling in scientific reasoning. Dynamical modeling uses, transforms, and constructs models which capture the causal and structural dynamics of given phenomena.
Dr. Ashok K. Goel (advisor +3 more
core
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Dynamical Modeling of the Core Gene Network Controlling Transition to Flowering in Pisum sativum. [PDF]
Front Genet, 2021 Pavlinova P, Samsonova MG, Gursky VV.
europepmc +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source