Results 161 to 170 of about 58,720 (307)
The Astrophysical JournalWe present the results of broad-line region (BLR) dynamical modeling for eight high-mass active galactic nuclei (AGNs) from the Seoul National University AGN Monitoring Project, by constraining BLR geometry and kinematics as well as black hole (BH) mass (
Shu Wang +4 more
doaj +1 more source
Dynamical Modeling of Optogenetic Circuits in Yeast for Metabolic Engineering Applications. [PDF]
ACS Synth Biol, 2021 Lovelett RJ +5 more
europepmc +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Proceedings of the 9th AIMS International Conference (Orlando, FL, USA), DCDS Supplement 2013
, 2013 Topics: Analysis, applied analysis, differential equations and dynamical systems, in the broadest sense. Applications to real-world problems, including chemical, economical, engineering, physical, environmental, and life sciences, in the forms of ...
Edited by David Costa, Differential E. q. u. a. t. i. o. n. s. +7 more
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Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Data-driven modeling of interrelated dynamical systems
Communications PhysicsNon-linear dynamical systems describe numerous real-world phenomena, ranging from the weather, to financial markets and disease progression. Individual systems may share substantial common information, for example patients’ anatomy. Lately, deep-learning
Yonatan Elul +5 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Effect of the Turbulence Modeling in the Prediction of Heat Transfer in Suction Mufflers
, 2012 The well-grounded knowledge of the available numerical methods is of fundamental importance to get advantage of computational aided design. Concerning compressor development, the employment of Computational Fluid Dynamics is nowadays a must, however ...
Rodrigues, Tadeu Tonheiro, Link, Rodrigo
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Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Dynamical modeling of miR-34a, miR-449a, and miR-16 reveals numerous DDR signaling pathways regulating senescence, autophagy, and apoptosis in HeLa cells. [PDF]
Sci Rep, 2022 Gupta S +7 more
europepmc +1 more source