Results 161 to 170 of about 333,427 (264)

Inter-subject and inter-parcellation variability of resting-state whole-brain dynamical modeling.

Neuroimage, 2021
Popovych OV, Jung K, Manos T, Diaz-Pier S, Hoffstaedter F, Schreiber J, Yeo BTT, Eickhoff SB.   +7 more
europepmc   +1 more source

Dynamical modeling predicts an inflammation-inducible CXCR7+ B cell precursor with potential implications in lymphoid blockage pathologies. [PDF]

PeerJ, 2020
Enciso J, Mendoza L, Álvarez-Buylla ER, Pelayo R.   +3 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Development and application of a novel tumor habitat analysis technique based on dynamical modeling. [PDF]

Med Phys
Stevens JB, Je J, Riley BA, Mowery YM, Brizel DM, Liu JG, Wang C, Lafata KJ.   +7 more
europepmc   +1 more source

Allosteric communication in molecular machines via information exchange: what can be learned from dynamical modeling. [PDF]

Biophys Rev, 2020
Loutchko D, Flechsig H.
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Dynamical modeling and data analysis of HIV infection with infection-age, CTLs immune response and delayed antibody immune response. [PDF]

J Math Biol
Li Y, Zhang L, Zhang J, Liu S, Peng Z.
europepmc   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Context-Aware Biosensor Design Through Biology-Guided Machine Learning and Dynamical Modeling. [PDF]

ACS Synth Biol
Tellechea-Luzardo J, Martin Lazaro H, Fernandez Perez C, Henriques D, Otero-Muras I, Carbonell P.   +5 more
europepmc   +1 more source