Results 231 to 240 of about 170,832 (317)

Mathematical and sensitivity analysis for chemical species in multistep dynamical system: A computational study. [PDF]

Heliyon
Sultan F, Ishaq MS.
europepmc   +1 more source

Tikhonov regularization of a second order dynamical system with Hessian driven damping. [PDF]

Math Program, 2021
Boţ RI, Csetnek ER, László SC.
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Unambiguous Models and Machine Learning Strategies for Anomalous Extreme Events in Turbulent Dynamical System. [PDF]

Entropy (Basel)
Qi D.
europepmc   +1 more source

Behavioral response of population on transmissibility and saturation incidence of deadly pandemic through fractional order dynamical system. [PDF]

Results Phys, 2021
Abdul Razzaq O, Alam Khan N, Faizan M, Ara A, Ullah S.   +4 more
europepmc   +1 more source

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source

Optimal Estimation of a Signal Generated Using a Dynamical System Modeled with McKean-Vlasov Stochastic Differential Equations. [PDF]

Entropy (Basel)
Dragan V, Aberkane S.
europepmc   +1 more source

From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care

Molecular Oncology, EarlyView.
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard, Flavie Bénard, Eva Billat, Margaux Le Guyon, Victoria Maltret, Laura Merlet, Chloé Astrid Walter, Tony Avril, Eric Chevet   +8 more
wiley   +1 more source

TimeTeller: A tool to probe the circadian clock as a multigene dynamical system. [PDF]

PLoS Comput Biol
Vlachou D, Veretennikova M, Usselmann L, Vasilyev V, Ott S, Bjarnason GA, Dallmann R, Levi F, Rand DA.   +8 more
europepmc   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source