Results 221 to 230 of about 763,790 (287)

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Who benefits from mobile health interventions? A dynamical systems analysis of psychological well-being in early adults. [PDF]

Appl Psychol Health Well Being
Heshmati S, Muth C, Li Y, Roeser RW, Smyth JM, Vandekerckhove J, Chow SM, Oravecz Z.   +7 more
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Quantized State Estimation for Linear Dynamical Systems. [PDF]

Sensors (Basel)
Bhaskara RR, Majji M, Guzmán F.
europepmc   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Effect of a national mental health campaign on population mental resilience in the Netherlands: a retrospective longitudinal cohort analysis using a dynamical systems perspective. [PDF]

Lancet Reg Health Eur
van der Wal JM, Pijpers F, Lunansky G, Lok A, Nicolaou M, Korezelidou A, Stronks K, Bockting CL.   +7 more
europepmc   +1 more source

Exploratory Analysis of ELP1 Expression in Whole Blood From Patients With Familial Dysautonomia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Familial dysautonomia (FD) is a hereditary neurodevelopmental disorder caused by aberrant splicing of the ELP1 gene, leading to a tissue‐specific reduction in ELP1 protein expression. Preclinical models indicate that increasing ELP1 levels can mitigate disease manifestations.
Alejandra González‐Duarte, Lucy Norcliffe‐Kaufmann, Maria Luisa Cotrina, Zenith Khan, Kaia Dalamo, Patricio Millar Vernetti, Matthew Lawless, Elisabetta Morini, Monica Salani, Marla Weetall, Jana Narasimhan, Agostino G. Rocha, Susan A. Slaugenhaupt, Horacio Kaufmann   +13 more
wiley   +1 more source

Changing temporal patterns in patient-reported wish to live and wish to die signal the imminent emergence and aftermath of suicide attempts: a dynamical systems analysis. [PDF]

BMC Psychiatry
Bryan CJ, Bozzay ML, Hay J, Starkey A, Tabares JV, Baker JC.   +5 more
europepmc   +1 more source

Exploring Simplicity Bias in 1D Dynamical Systems. [PDF]

Entropy (Basel)
Dingle K, Alaskandarani M, Hamzi B, Louis AA.   +3 more
europepmc   +1 more source

Dynamical Systems on Graph Limits and Their Symmetries. [PDF]

J Dyn Differ Equ
Bick C, Sclosa D.
europepmc   +1 more source