Results 51 to 60 of about 75,284 (269)

Modeling drug retention as memory effects in obese patients using fractional and augmented models

Scientific Reports
Lipophilic anesthetic drugs accumulate in adipose tissue, leading to delayed release and prolonged effects, particularly in obese patients. This study proposes two novel physiologically motivated pharmacokinetic (PK) models to address these dynamics. The
Amani R. Ynineb, Erhan Yumuk, Dana Copot, Bora Ayvaz, Bouchra Khoumeri, Ghada Ben Othman, Marcian D. Mihai, Isabela R. Birs, Cristina I. Muresan, Clara M. Ionescu   +9 more
doaj   +1 more source

Lagrangian simulation and tracking of the mesoscale eddies contaminated by Fukushima-derived radionuclides [PDF]

Ocean Science, 2017
A Lagrangian methodology is developed to simulate, track, document and analyze the origin and history of water masses in ocean mesoscale features.
S. V. Prants, M. V. Budyansky, M. Y. Uleysky   +2 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Lagrangian study of surface transport in the Kuroshio Extension area based on simulation of propagation of Fukushima-derived radionuclides [PDF]

Nonlinear Processes in Geophysics, 2014
Lagrangian approach is applied to study near-surface large-scale transport in the Kuroshio Extension area using a simulation with synthetic particles advected by AVISO altimetric velocity field.
S. V. Prants, M. V. Budyansky, M. Yu. Uleysky   +2 more
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Statistical analysis of Lagrangian transport of subtropical waters in the Japan Sea based on AVISO altimetry data [PDF]

Nonlinear Processes in Geophysics, 2017
Northward near-surface Lagrangian transport of subtropical waters in the Japan Sea frontal zone is simulated and analysed based on altimeter data for the period from 2 January 1993 to 15 June 2015.
S. V. Prants, M. V. Budyansky, M. Yu. Uleysky   +2 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Modulation Instability Analysis, Solitary Wave Solutions, Dark Soliton Solutions, and Complexitons for the (3 + 1)-Dimensional Nonlinear Schrödinger Equation

Journal of Mathematics, 2022
This paper addresses the (3 + 1)-dimensional nonlinear Schrödinger equation, which could be utilized to express many physical media the envelope of the wave amplitude.
Chun-Yan Qin
doaj   +1 more source