Results 111 to 120 of about 64,512 (339)

Thermodynamic and dynamical predictions for bifurcations and non-equilibrium phase transitions

Communications Physics, 2023
“Critical transitions”, in which systems switch abruptly from one state to another are ubiquitous in physical and biological systems. Such critical transitions in complex systems are commonly described as dynamical processes within the framework of ...
Han Yan, Feng Zhang, Jin Wang
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

A dynamical systems approach to micro spacecraft autonomy [PDF]

, 2010
The drive toward reducing the size and mass of spacecraft has put new constraints on the computational resources available for control and decision making algorithms.
McInnes, Colin, Brown, Blair, McInnes, C.R.   +2 more
core  

Spectral Sequences In Conleys Theory [PDF]

, 2015
In this paper, we analyse the dynamics encoded in the spectral sequence (Er,dr) associated with certain Conley theory connection maps in the presence of an action type filtration.
Da Silveira M.R., De Rezende K.A., Cornea O.   +2 more
core   +1 more source

Theoretical Principles of Multiscale Spatiotemporal Control of Neuronal Networks: A Complex Systems Perspective

Frontiers in Computational Neuroscience, 2018
Success in the fine control of the nervous system depends on a deeper understanding of how neural circuits control behavior. There is, however, a wide gap between the components of neural circuits and behavior.
Nima Dehghani, Nima Dehghani
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Extreme value laws in dynamical systems under physical observables [PDF]

, 2012
Extreme value theory for chaotic deterministic dynamical systems is a rapidly expanding area of research. Given a system and a real function (observable) defined on its phase space, extreme value theory studies the limit probabilistic laws obeyed by ...
Holland, Mark P., Renato Vitolo, Sterk, Alef E., Sterk, Alef E.; id_orcid, Vitolo, Renato,, Henk W. Broer, Holland, Mark P.,, Sterk, Alef E.,, Rabassa, Pau,, Mark P. Holland, Alef E. Sterk, Rabassa, Pau, Pau Rabassa, Broer, Hendrik; id_orcid, Vitolo, Renato, Broer, Henk W.,, Broer, Hendrik   +16 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source