Results 91 to 100 of about 534,870 (272)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Behavior as Physiology: How Dynamical-Systems Theory Could Advance Psychiatry. [PDF]
Am J Psychiatry, 2021 Salvi JD, Rauch SL, Baker JT.
europepmc +1 more source
Dynamical Systems Theory and Explanatory Indispensability [PDF]
Philosophy of Science, 2017 I examine explanations’ realist commitments in relation to dynamical systems theory. First I rebut an ‘explanatory indispensability argument’ for mathematical realism from the explanatory power of phase spaces. Then I critically consider a possible way of strengthening the indispensability argument by reference to attractors in dynamical systems theory.
openaire +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Dynamic Equations, Control Problems on Time Scales, and Chaotic Systems
Chaos Theory and Applications, 2023 The unification of integral and differential calculus with the calculus of finite differences has been rendered possible by providing a formal structure to study hybrid discrete-continuous dynamical systems besides offering applications in diverse fields
Martin Bohner
doaj
Entropy, 2008 We give a survey of the basic statistical ideas underlying the definition of entropy in information theory and their connections with the entropy in the theory of dynamical systems and in statistical mechanics.
Derek W. Robinson
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Interpretable predictions of chaotic dynamical systems using dynamical system deep learning
Scientific ReportsMaking accurate predictions of chaotic dynamical systems is an essential but challenging task with many practical applications in various disciplines.
Mingyu Wang, Jianping Li
doaj +1 more source
A central limit theorem for random dynamical systems
上海师范大学学报. 自然科学版, 2019 In this article, we establish a central limit theorem (CLT) for random dynamical systems (RDS), which is a supplement to the ergodic theory of random dynamical system.
LYU Kening, ZHENG Yan
doaj +1 more source