Results 81 to 90 of about 13,879,059 (294)
Automated global analysis of experimental dynamics through low-dimensional linear embeddings
npj ComplexityDynamical systems theory has long provided a foundation for understanding evolving phenomena across scientific domains. Yet, the application of this theory to complex real-world systems remains challenging due to issues in mathematical modeling ...
Samuel A. Moore +2 more
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Entropy, 2014 Advances in neuroscience have been closely linked to mathematical modeling beginning with the integrate-and-fire model of Lapicque and proceeding through the modeling of the action potential by Hodgkin and Huxley to the current era.
Wassim M. Haddad +2 more
doaj +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Birkhoff sum fluctuations in substitution dynamical systems
, 2019 We consider the deviation of Birkhoff sums along fixed orbits of substitution dynamical systems. We show distributional convergence for the Birkhoff sums of eigen functions of the substitution matrix.
Elliot Paquette, SON, YOUNGHWAN
core +1 more source
ERGODIC OPTIMIZATION IN DYNAMICAL SYSTEMS [PDF]
, 2017 Ergodic optimization is the study of problems relating to maximizing orbits and invariant measures, and maximum ergodic averages. An orbit of a dynamical system is called -maximizing if the time average of the real-valued function along the orbit is ...
JENKINSON, OM, OLIVER JENKINSON
core +1 more source
On the Relation between Topological Entropy and Restoration Entropy
Entropy, 2018 In the context of state estimation under communication constraints, several notions of dynamical entropy play a fundamental role, among them: topological entropy and restoration entropy. In this paper, we present a theorem that demonstrates that for most
Christoph Kawan
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Frontiers in Computational Neuroscience, 2018 Success in the fine control of the nervous system depends on a deeper understanding of how neural circuits control behavior. There is, however, a wide gap between the components of neural circuits and behavior.
Nima Dehghani, Nima Dehghani
doaj +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source