Results 61 to 70 of about 534,870 (272)

Dynamical stability and chaos in artificial neural network trajectories along training

Frontiers in Complex Systems
The process of training an artificial neural network involves iteratively adapting its parameters so as to minimize the error of the network’s prediction, when confronted with a learning task.
Kaloyan Danovski, Miguel C. Soriano, Lucas Lacasa   +2 more
doaj   +1 more source

Global theory of nonlinear systems-chaos, knots and stability [PDF]

Acta Montanistica Slovaca, 2003
In this paper we shall give a brief overview of nonlinear dynamical systems theory including the theory of chaos, knots, approximation theory and stability.
Banks Stephen P.
doaj  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Automated global analysis of experimental dynamics through low-dimensional linear embeddings

npj Complexity
Dynamical systems theory has long provided a foundation for understanding evolving phenomena across scientific domains. Yet, the application of this theory to complex real-world systems remains challenging due to issues in mathematical modeling ...
Samuel A. Moore, Brian P. Mann, Boyuan Chen   +2 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

On the Relation between Topological Entropy and Restoration Entropy

Entropy, 2018
In the context of state estimation under communication constraints, several notions of dynamical entropy play a fundamental role, among them: topological entropy and restoration entropy. In this paper, we present a theorem that demonstrates that for most
Christoph Kawan
doaj   +1 more source

Thermodynamic and dynamical predictions for bifurcations and non-equilibrium phase transitions

Communications Physics, 2023
“Critical transitions”, in which systems switch abruptly from one state to another are ubiquitous in physical and biological systems. Such critical transitions in complex systems are commonly described as dynamical processes within the framework of ...
Han Yan, Feng Zhang, Jin Wang
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Human Brain Networks: Spiking Neuron Models, Multistability, Synchronization, Thermodynamics, Maximum Entropy Production, and Anesthetic Cascade Mechanisms

Entropy, 2014
Advances in neuroscience have been closely linked to mathematical modeling beginning with the integrate-and-fire model of Lapicque and proceeding through the modeling of the action potential by Hodgkin and Huxley to the current era.
Wassim M. Haddad, Qing Hui, James M. Bailey   +2 more
doaj   +1 more source