Results 101 to 110 of about 5,067,506 (313)
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Discrete Dynamics in Nature and Society, 2023 Discrete Dynamics in Nature and Society
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Reducing childhood overweight and obesity : can the target be reached by 2025?
, 2017 The increasing prevalence of childhood overweight and obesity is raising significant concern about lasting health effects on individuals, as well as social and economic impacts.
Heffernan, Mark (R20258) +7 more
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FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
The Fear Management Model: Building an Integrative Fear Appeal Theory through System Dynamics [PDF]
, 2016 This paper attempts to refine the Extended Parallel Process Model by adding the notion of hope to highlight the significant role of fear in fear appeals.
Han, Charles C.
core +1 more source
, 2009 Multibody dynamics underlies modeling projects for undergraduate students at the Université catholique de Louvain (UCL, Belgium) since 1995. Being still very active in this field – about hundred students/year dealing with a MBS-based project – we are now
Samin, Jean-Claude +3 more
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Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
A Scaled-Bogie Test Bench to Understand and Demystify Wheel-Rail Contact Dynamics
, 2011 It is a well-known fact that railway dynamics is far from being trivial, mostly because of the wheel/rail contact phenomenon. Except for specialists in this field who are obviously familiar with notions like wheelset equivalent conicity, hunting motion ...
Docquier, Nicolas +2 more
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