Results 111 to 120 of about 168,786,670 (266)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

How to decarbonise energy-intensive processing industries?: Survey and conceptualisation of their specific innovation systems [PDF]

, 2016
Energy-intensive processing industries (EPIs) such as iron and steel, aluminum, chemicals, cement, glass, and paper and pulp are responsible for a large share of global greenhouse gas emissions.
Nilsson, L.J., Coenen, Lars, Ahman, M., Energy, Resources & Technological Change, Energy and Resources, Lechtenbohmer, S., Wesseling, J.H., Innovation Studies, Worrell, E., Dynamics of Innovation Systems   +9 more
core  

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Indigenous Lands inhibit mining-induced deforestation in the Brazilian Amazon

Global Ecology and Conservation
Indigenous Lands (ILs) have been recognized as valuable tools for Amazon conservation. Originally established to protect indigenous rights and culture, they have unintentionally become essential for environmental conservation. ILs cover approximately 23 %
Luiz Guilherme dos Santos Ribas, Mauro Galetti   +1 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Characteristics of an Inorganic Carbon Sink Influenced by Agricultural Activities in the Karst Peak Cluster Depression of Southern China (Guancun)

Land
Land use in karst areas affects soil properties, impacting carbon sinks. Accurate estimation of carbon sink flux in karst areas through zoning and classification is crucial for understanding global carbon cycling and climate change.
Ning Zhang, Qiong Xiao, Yongli Guo, Pingan Sun, Ying Miao, Fajia Chen, Cheng Zhang   +6 more
doaj   +1 more source

Phenology and carbon dioxide source/sink strength of a subalpine grassland in response to an exceptionally short snow season

Environmental Research Letters, 2013
Changes in snow cover depth and duration predicted by climate change scenarios are expected to strongly affect high-altitude ecosystem processes. This study investigates the effect of an exceptionally short snow season on the phenology and carbon dioxide
M Galvagno, G Wohlfahrt, E Cremonese, M Rossini, R Colombo, G Filippa, T Julitta, G Manca, C Siniscalco, U Morra di Cella, M Migliavacca   +10 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Eliasch Review

, 2008
According to the Office of Climate Change press release, the Eliasch Review aims to provide an analysis of international financing to reduce forest loss and its associated impacts on climate change.
Great Britain. Office of Climate Change, Eliasch, Johan   +1 more
core  

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source