Results 121 to 130 of about 168,786,670 (266)

Impact of Climate events over the Last Glacial-Interglacial Transition [PDF]

, 2013
The time period from 60-8 ka cal BP is marked by a series of abrupt climate events that became apparent from especially the Greenland Ice core records.
Geomorfologie, Hoek, Wim, Coastal dynamics, Fluvial systems and Global change, WG4Members, Intimate, Birks, Hilary   +4 more
core  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Seeds of Change

, 2008
How did the 20th century change the way Americans live? This ABC News program anchored by Peter Jennings examines daily life during the early 1900s--when William McKinley was President, a loaf of bread cost only a few cents, horsepower really meant ...

core  

The GFDL Variable‐Resolution Global Chemistry‐Climate Model for Research at the Nexus of US Climate and Air Quality Extremes

Journal of Advances in Modeling Earth Systems
We present a variable‐resolution global chemistry‐climate model (AM4VR) developed at NOAA's Geophysical Fluid Dynamics Laboratory (GFDL) for research at the nexus of US climate and air quality extremes. AM4VR has a horizontal resolution of 13 km over the
Meiyun Lin, Larry W. Horowitz, Ming Zhao, Lucas Harris, Paul Ginoux, John Dunne, Sergey Malyshev, Elena Shevliakova, Hamza Ahsan, Steve Garner, Fabien Paulot, Arman Pouyaei, Steven J. Smith, Yuanyu Xie, Niki Zadeh, Linjiong Zhou   +15 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Our changing planet : the U.S. Climate Change Science Program for fiscal years ... : a report

, 2003
Annual report of the U.S. Climate Change Science Program documenting activities and research, goals for the upcoming year, proposed budget considerations, and other information about the organization for fiscal year ...
Climate Change Science Program (U.S.)
core  

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Dynamics of Continuity and Change in Jewish Religious Life

Presents a group of distinguished scholars who examine key themes in Jewish religious life. Essays revolve around the dynamics of religious continuity and change.
Levine, Eric., Fishbane, Simcha.
core  

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Thermodynamic effect dictates influence of the Atlantic Multidecadal Oscillation on Eurasia winter temperature

npj Climate and Atmospheric Science
The Atlantic Multidecadal Oscillation (AMO) has garnered attention for its important role in shaping surface air temperature (SAT) patterns over Eurasia.
Huan Wang, Zhiyan Zuo, Renhe Zhang, Li Peng, Kaiwen Zhang, Deliang Chen, Dong Xiao, Qinglong You, Guokun Dai, Ruonan Zhang, Haijun Yang, Xiaodan Chen, Zouxing Lin, Peiqiang Xu, Liang Qiao   +14 more
doaj   +1 more source