Results 71 to 80 of about 168,786,670 (266)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

The Palimpsest of River-Floodplain Management and the Role of Geomorphology [PDF]

, 2015
Embanked floodplains are the status-quo where humans are a major component of the environment, especially across Europe and North America. Effective management of embanked rivers requires a comprehensive knowledge of past and present-day geomorphic ...
Hans Middelkoop, Geomorfologie, Hudson, Paul F, Coastal dynamics, Fluvial systems and Global change, Paul F. Hudson, Middelkoop, Hans   +5 more
core   +1 more source

From Static to Spatiotemporal: Dynamic Volatility Distribution Parameterizations for Global Organic Aerosol Simulations

Journal of Advances in Modeling Earth Systems
Organic aerosols (OA) are a major component of fine particulate matter that affects air quality and climate, yet atmospheric models often underestimate their concentrations, partly reflecting uncertainties in the assumed volatility distribution of ...
Mingxinyu Lu, Chloe Yuchao Gao
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Evidence for a transgressive barrier within a regressive strandplain system: Implications for a complex coastal response to environmental change [PDF]

, 2013
Clastic, depositional strandplain systems have the potential to record changes in the primary drivers of coastal evolution: climate, sea-level, and the frequency of major meteorological and oceanographic events.
Coastal dynamics, Fluvial systems and Global change, Hein, Christopher J., Cleary, William J., Menezes, João Thadeu de, FitzGerald, Duncan M., Klein, Antonio H. da F., Boechat Albernaz, M.   +6 more
core   +1 more source

Suppression of Plant Resistance May Be a Common Trait Among Adapted Herbivores

Ecology and Evolution
Herbivores have evolved distinct strategies to cope with plant defenses prior to becoming a pest. Some evolved resistance to toxic compounds; others suppress host toxin production.
Jéssica Teodoro‐Paulo, Carlos Fernandes, Lin Dong, Sara Magalhães, Alison B. Duncan, Juan M. Alba, Merijn R. Kant   +6 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Characteristics of saw-tooth bars on the ebb-tidal deltas of the Wadden Islands [PDF]

, 2019
Saw-tooth bars are shore-oblique sand bars that are found along most ebb-tidal deltas of the Frisian Wadden Islands. Although they might significantly affect sediment transport pathways and volumes on the deltas, their general characteristics and ...
Coastal dynamics, Fluvial systems and Global change, Brakenhoff, L.B., Ruessink, B.G., Proceskunde, van der Vegt, M.   +4 more
core   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Subfossil European bog oaks: population dynamics and long-term growth depressions as indicators of changes in the Holocene hydro-regime and climate [PDF]

, 2002
Some 2600 bog oaks have been dated from German, Dutch and Irish bogs covering the period 6000 bc to ad 1000. The ring patterns of these ‘bog oaks’ are characterized by recurrent, long-term growth depressions.
Jansma, E, Coastal dynamics, Fluvial systems and Global change, Leuschner, Hanns-Hubert, Leuschner, H.H., Baillie, M., Baillie, M.G.L., Spurk, M., Sass-Klaassen, U., Baillie, MGL, Jansma, E.   +9 more
core   +1 more source