Results 71 to 80 of about 934,318 (260)

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source

Indigenous Lands inhibit mining-induced deforestation in the Brazilian Amazon

Global Ecology and Conservation
Indigenous Lands (ILs) have been recognized as valuable tools for Amazon conservation. Originally established to protect indigenous rights and culture, they have unintentionally become essential for environmental conservation. ILs cover approximately 23 %
Luiz Guilherme dos Santos Ribas, Mauro Galetti   +1 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Phenology and carbon dioxide source/sink strength of a subalpine grassland in response to an exceptionally short snow season

Environmental Research Letters, 2013
Changes in snow cover depth and duration predicted by climate change scenarios are expected to strongly affect high-altitude ecosystem processes. This study investigates the effect of an exceptionally short snow season on the phenology and carbon dioxide
M Galvagno, G Wohlfahrt, E Cremonese, M Rossini, R Colombo, G Filippa, T Julitta, G Manca, C Siniscalco, U Morra di Cella, M Migliavacca   +10 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Characteristics of an Inorganic Carbon Sink Influenced by Agricultural Activities in the Karst Peak Cluster Depression of Southern China (Guancun)

Land
Land use in karst areas affects soil properties, impacting carbon sinks. Accurate estimation of carbon sink flux in karst areas through zoning and classification is crucial for understanding global carbon cycling and climate change.
Ning Zhang, Qiong Xiao, Yongli Guo, Pingan Sun, Ying Miao, Fajia Chen, Cheng Zhang   +6 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

The GFDL Variable‐Resolution Global Chemistry‐Climate Model for Research at the Nexus of US Climate and Air Quality Extremes

Journal of Advances in Modeling Earth Systems
We present a variable‐resolution global chemistry‐climate model (AM4VR) developed at NOAA's Geophysical Fluid Dynamics Laboratory (GFDL) for research at the nexus of US climate and air quality extremes. AM4VR has a horizontal resolution of 13 km over the
Meiyun Lin, Larry W. Horowitz, Ming Zhao, Lucas Harris, Paul Ginoux, John Dunne, Sergey Malyshev, Elena Shevliakova, Hamza Ahsan, Steve Garner, Fabien Paulot, Arman Pouyaei, Steven J. Smith, Yuanyu Xie, Niki Zadeh, Linjiong Zhou   +15 more
doaj   +1 more source