Results 81 to 90 of about 168,786,670 (266)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Voices of Change: April 12, 1982
, 1982 A concert recording of the April 12, 1982 performance of the Voices of Change music ensemble. The Voices of Change music ensemble performs works by 20th and 21st century composers. [piece 1] Canto/ Robert Xavier Rodriguez [piece 2] Duendecitos!
Voices of Change (Musical group)
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Flood frequency analysis and discussion of non-stationarity of the Lower Rhine flooding regime (AD 1350–2011): Using discharge data, water level measurements, and historical records [PDF]
, 2015 Accurate estimates of the recurrence time of extreme floods are essential to assess flood safety in flood-prone regions, such as the Lower Rhine in The Netherlands. Measured discharge records have a limited length and are, in general, poorly representing
Geomorfologie +2 more
core +2 more sources
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Potential effects of climate change .... Spanish
, 2023 Title from PDF caption (viewed on February 9, 2023).This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program.
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Turning points in climate change adaptation [PDF]
, 2015 Concerned decision makers increasingly pose questions as to whether current management practices are able to cope with climate change and increased climate variability.
Trombi, Giacomo +18 more
core +1 more source
China Geology, 2018 : On the basis of proposing the existence of a karst carbon cycle and carbon sink at a watershed scale, this paper provides four pieces of evidence for the integration of geology and ecology during the carbon cycle processes in the karst dynamic system ...
Jian-hua Cao +6 more
doaj +1 more source
Modelling the dynamics of change in the technical skills of young basketball players: The INEX study. [PDF]
PLoS One, 2021 Guimarães E +5 more
europepmc +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source