Results 41 to 50 of about 42,989 (261)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Educational and legal aspects of activities of out-of-school educational institutions
Науковий Вісник Південноукраїнського Національного Педагогічного Університету імені К. Д. Ушинського, 2020 The article deals with the historical process of formation of educational and legal support for the activities of out-of-school educational institutions during the independence of Ukraine.
Ilchenko Оlena, Kobobel Alla
doaj +1 more source
Institutions, education inequality and dynamics of institutional reform
, 2009 This dissertation consists of four studies on the role of institutions, education and institutional reform in economic development. Three of the studies examine empirical aspects of the issue and the fourth provides an analysis of policy implications.
openaire +2 more sources
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
The Issue of Islamic Higher Education Development in Indonesia from 1945 to Present
Yupa: Historical Studies JournalThis research aims to analyze the issues surrounding the development of Islamic Higher Education through the application of literature review methodology.
Sugianto Sugianto +4 more
doaj +1 more source
Journal of Information Systems and Informatics, 2021 This article aims to analyze the dynamics of information systems design using a structured model, based on the year of publication, the scope of application of information systems, and the information system platform designed (website, desktop, mobile).
Yerik Afrianto Singgalen
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Jurnal Pendidikan Islam, 2016 This writing is to elaborate the idea of reconstructing system of Pesantren. This is due to the demand of real social needs and competition on the quality among educational institutions. As a result, reconstructing education system of Pesantren is a must
Husnul Amin
doaj +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source