Results 131 to 140 of about 23,034 (262)
Locus coeruleus to basolateral amygdala noradrenergic projections promote anxiety-like behavior [PDF]
, 2017 Increased tonic activity of locus coeruleus noradrenergic (LC-NE) neurons induces anxiety-like and aversive behavior. While some information is known about the afferent circuitry that endogenously drives this neural activity and behavior, the downstream ...
Bhatti, Dionnet L. +6 more
core +3 more sources
Minocycline prevents dynorphin-induced neurotoxicity during neuropathic pain in rats.
Neuropharmacology, 2014 Despite many advances, our understanding of the involvement of prodynorphin systems in the development of neuropathic pain is not fully understood. Recent studies suggest an important role of neuro-glial interactions in the dynorphin effects associated ...
E. Rojewska +3 more
semanticscholar +1 more source
Dopaminergic, glutamatergic but not opioidergic mechanisms mediate induction of FOS-like protein by cocaethylene [PDF]
, 1997 Cocaethylene is a psychoactive metabolite formed\ud during the combined consumption of cocaine and ethanol. As\ud this metabolite has many properties in common with cocaine, it is conceivable that cocaethylene administration may induce the activity of ...
DiPirro, Dr. J.M. +3 more
core
Substance P regulates puberty onset and fertility in the female mouse [PDF]
, 2015 Puberty is a tightly regulated process that leads to reproductive capacity. Kiss1 neurons are crucial in this process by stimulating GnRH, yet how Kiss1 neurons are regulated remains unknown. Substance P (SP), an important neuropeptide in pain perception,
Carroll, R.S. +7 more
core +1 more source
The Dysphoric Component of Stress Is Encoded by Activation of the Dynorphin κ-Opioid System
Journal of Neuroscience, 2008 Stress is a complex human experience having both positive and negative motivational properties. When chronic and uncontrollable, the adverse effects of stress on human health are considerable and yet poorly understood.
Benjamin Land +5 more
semanticscholar +1 more source
Frontiers in Molecular Neuroscience, 2012 The brain is constantly exposed to external and internal input and to function in an ever-changing environment we are dependent on processes that enable the brain to adapt to new stimuli.
Ingrid eNylander, Erika eRoman
doaj +1 more source
Individual differences in the neuropsychopathology of addiction. [PDF]
, 2017 Drug addiction or substance-use disorder is a chronically relapsing disorder that progresses through binge/intoxication, withdrawal/negative affect and preoccupation/anticipation stages.
George, Olivier, Koob, George F
core
International Journal of Reproductive BioMedicineBackground: Since kisspeptin (KISS1) in the hypothalamus is affected by the inhibitory effect of dynorphin, it raises questions about the controlled balance of these 2 neuropeptides in women with and without polycystic ovary syndrome (PCOS).
Andon Hestiantoro +7 more
doaj +1 more source
Stress rapidly suppresses in vivo LH pulses and increases activation of RFRP-3 neurons in male mice [PDF]
, 2018 Restraint stress is a psychosocial stressor that suppresses reproductive status, including LH pulsatile secretion, but the neuroendocrine mechanisms underlying this inhibition remains unclear.
Hughes, Jessica K +4 more
core +1 more source
Structural basis of divergent substrate recognition and inhibition of human neurolysin
Scientific ReportsA zinc metallopeptidase neurolysin (Nln) processes diverse bioactive peptides to regulate signaling in the mammalian nervous system. To understand how Nln interacts with various peptides with dissimilar sequences, we determined crystal structures of Nln ...
Ke Shi +7 more
doaj +1 more source