Frontiers in Endocrinology, 2021 Increasing evidence accumulated during the past two decades has demonstrated that the then-novel kisspeptin, which was discovered in 2001, the known neuropeptides neurokinin B and dynorphin A, which were discovered in 1983 and 1979, respectively, and ...
Yoshihisa Uenoyama +4 more
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Effect of neurokinin B and dynorphin A on kisspeptin-10 secretion from the anterior pituitary cells of pubescent ewes in vitro [PDF]
Journal of Veterinary ResearchNeurokinin B (NKB), dynorphin A (Dyn A) and kisspeptin (KiSS) are key agents that participate in the neuroendocrine regulation of the development and functioning of the reproductive system.
Szysiak Natalia +5 more
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Microiontophoretic Application of Dynorphin in Dental Pain: Excitatory or Inhibitory Effects [PDF]
Journal of Pain ResearchSeung-Ho Choi,* Yu-Mi Kim,* Jo-Young Son, Dong-Kuk Ahn Department of Oral Physiology, School of Dentistry, Kyungpook National University, Daegu, Korea*These authors contributed equally to this workCorrespondence: Dong-Kuk Ahn, Department of ...
Choi SH, Kim YM, Son JY, Ahn DK
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Influence of neurokinin B, dynorphin A and kisspeptin-10 on in vitro gonadotropin secretion by anterior pituitary cells isolated from pubescent ewes [PDF]
Journal of Veterinary ResearchThe hypothalamic neuropeptides kisspeptin-10 (KiSS-10), neurokinin B (NKB), and dynorphin A (Dyn A) play roles in the endocrine regulation of the hypothalamic–pituitary–ovarian (HPO) axis in puberty.
Szysiak Natalia +7 more
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Enhanced dynorphin expression and secretion in pancreatic beta-cells under hyperglycemic conditions [PDF]
Molecular MetabolismObjective: Dynorphin, an endogenous opioid peptide predominantly expressed in the central nervous system and involved in stress response, pain, and addiction, has intrigued researchers due to its expression in pancreatic β-cells.
Miranda Movahed +2 more
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Ginsenoside Re protects methamphetamine-induced dopaminergic neurotoxicity in mice via upregulation of dynorphin-mediated κ-opioid receptor and downregulation of substance P-mediated neurokinin 1 receptor [PDF]
Journal of Neuroinflammation, 2018 Background We previously reported that ginsenoside Re (GRe) attenuated against methamphetamine (MA)-induced neurotoxicity via anti-inflammatory and antioxidant potentials.
Duy-Khanh Dang +12 more
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Journal of Neuroinflammation, 2020 Background Isotalatizidine is a representative C19-diterpenoid alkaloid extracted from the lateral roots of Aconitum carmichaelii, which has been widely used to treat various diseases on account of its analgesic, anti-inflammatory, anti-rheumatic, and ...
Shuai Shao +10 more
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Bullatine A stimulates spinal microglial dynorphin A expression to produce anti-hypersensitivity in a variety of rat pain models [PDF]
Journal of Neuroinflammation, 2016 Aconiti brachypodi Radix (Xue-shang-yi-zhi-hao) has been prescribed to manage chronic pain, arthritis, and traumatic injuries. Bullatine A, a C20-diterpenoid alkaloid, is one of its principle effective compounds.
Qian Huang +6 more
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A Bicyclic Analog of the Linear Peptide Arodyn Is a Potent and Selective Kappa Opioid Receptor Antagonist [PDF]
MoleculesKappa opioid receptor (KOR) antagonists have potential therapeutic applications in the treatment of stress-induced relapse to substance abuse and mood disorders.
Solomon A. Gisemba +3 more
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Label-free, real-time monitoring of membrane binding events at zeptomolar concentrations using frequency-locked optical microresonators [PDF]
Nature CommunicationsG-protein coupled receptors help regulate cellular function and communication, and are targets of small molecule drug discovery efforts. Conventional techniques to probe these interactions require labels and large amounts of receptor to achieve ...
Adley Gin +6 more
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