Microiontophoretic Application of Dynorphin in Dental Pain: Excitatory or Inhibitory Effects. [PDF]
J Pain ResSeung-Ho Choi,* Yu-Mi Kim,* Jo-Young Son, Dong-Kuk Ahn Department of Oral Physiology, School of Dentistry, Kyungpook National University, Daegu, Korea*These authors contributed equally to this workCorrespondence: Dong-Kuk Ahn, Department of ...
Choi SH, Kim YM, Son JY, Ahn DK.
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CRF1-R activation of the dynorphin/kappa opioid system in the mouse basolateral amygdala mediates anxiety-like behavior. [PDF]
PLoS ONE, 2009 Stress is a complex human experience and having both rewarding and aversive motivational properties. The adverse effects of stress are well documented, yet many of underlying mechanisms remain unclear and controversial. Here we report that the anxiogenic
Michael R Bruchas +3 more
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A Bicyclic Analog of the Linear Peptide Arodyn Is a Potent and Selective Kappa Opioid Receptor Antagonist. [PDF]
MoleculesKappa opioid receptor (KOR) antagonists have potential therapeutic applications in the treatment of stress-induced relapse to substance abuse and mood disorders.
Gisemba SA +3 more
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Estradiol treatment prevents injury induced enhancement in spinal cord dynorphin expression. [PDF]
Frontiers in Physiology, 2012 Administration of the ovarian steroid estradiol in male and female animals has been shown to have neuromodulatory and neuroprotective effects in a variety of experimental models. In the present study, spinal tissues from dermatomes just above (T5-7, at
Daya S. Gupta, Charles H. Hubscher
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Co‐Expression of Tardive Dyskinesia and Drug‐Induced Parkinsonism in Rats Chronically Treated With Haloperidol [PDF]
Neuropsychopharmacol RepRats chronically treated with haloperidol exhibit drug‐induced parkinsonism and tardive dyskinesia. Expression of dynorphin, enkephalin, and dopamine D1 and D2 receptors was altered in haloperidol‐treated rats. Both indirect and direct pathways are involved in haloperidol‐induced movement disorders.
Kinoshita I +7 more
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Ginsenoside Re protects methamphetamine-induced dopaminergic neurotoxicity in mice via upregulation of dynorphin-mediated κ-opioid receptor and downregulation of substance P-mediated neurokinin 1 receptor [PDF]
Journal of Neuroinflammation, 2018 Background We previously reported that ginsenoside Re (GRe) attenuated against methamphetamine (MA)-induced neurotoxicity via anti-inflammatory and antioxidant potentials.
Duy-Khanh Dang +12 more
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Label-free, real-time monitoring of membrane binding events at zeptomolar concentrations using frequency-locked optical microresonators. [PDF]
Nat CommunG-protein coupled receptors help regulate cellular function and communication, and are targets of small molecule drug discovery efforts. Conventional techniques to probe these interactions require labels and large amounts of receptor to achieve ...
Gin A +6 more
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Malnutrition alters protein expression of KNDy neuropeptides in the arcuate nucleus of mature ewes. [PDF]
Front PhysiolThe neuropeptides kisspeptin, neurokinin B, and dynorphin A are imperative for the pulsatile secretion of gonadotropin-releasing hormone and luteinizing hormone to ultimately regulate reproductive cyclicity.
Thorson JF, Prezotto LD.
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The degradation of dynorphin A in brain tissue in vivo and in vitro [PDF]
, 1987 The demonstration of analgesia following in vivo administration of dynorphin A (Dyn A) has been difficult. In contrast, a number of electrophysiological and behavioral effects reported with in vivo injection of Dyn A can be produced by des-tyrosine ...
Elizabeth A. Young +3 more
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Structural basis of divergent substrate recognition and inhibition of human neurolysin. [PDF]
Sci RepA zinc metallopeptidase neurolysin (Nln) processes diverse bioactive peptides to regulate signaling in the mammalian nervous system. To understand how Nln interacts with various peptides with dissimilar sequences, we determined crystal structures of Nln ...
Shi K +7 more
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