Results 211 to 220 of about 18,492 (264)

Dynorphin A activates bradykinin receptors to maintain neuropathic pain

Nature Neuroscience, 2006
Dynorphin A is an endogenous opioid peptide that produces non-opioid receptor-mediated neural excitation. Here we demonstrate that dynorphin induces calcium influx via voltage-sensitive calcium channels in sensory neurons by activating bradykinin receptors.
Josephine, Lai, Miaw-Chyi, Luo, Qingmin, Chen, Shouwu, Ma, Luis R, Gardell, Michael H, Ossipov, Frank, Porreca   +6 more
exaly   +3 more sources

Rimorphin (dynorphin B) exists together with α-neo-endorphin and dynorphin (dynorphin A) in human hypothalamus

Biochemical and Biophysical Research Communications, 1983
Rimorphin (dynorphin B) has been demonstrated to exist together with alpha-neo-endorphin and dynorphin(1-17) (dynorphin A) in the human hypothalamus. The content of rimorphin was comparable to that of alpha-neo-endorphin and somewhat higher than that of dynorphin. This result is quite similar to the recent observations in bovine, porcine and rat neural
K, Nakao, T, Yoshimasa, M, Suda, M, Sakamoto, Y, Ikeda, K, Hayashi, H, Imura   +6 more
openaire   +2 more sources

Dynorphin(1–10)amide: A potent and selective analog of dynorphin(1–13)

Life Sciences, 1982
Dynorphin(1-10)amide was more potent than Dynorphin(1-13) in inhibiting the twitch of the mouse vas deferens (IC50 of Dynorphin(1-10)amide = 0.3 nM and IC50 of Dynorphin (1-13) = 4.0 nM). Binding assays indicated that two opioid peptides had similar profiles in that they enhanced dihydromorphine (DHM) binding in picomolar concentrations but displaced ...
S, Woo, J, Garzon, P, Sanchez-Blazquez, F C, Tulunay, J K, Chang, H H, Loh   +5 more
openaire   +2 more sources

Dynorphins other than dynorphin A(1-17) lack spinal antianalgesic activity but do act on dynorphin A(1-17) receptors.

The Journal of Pharmacology and Experimental Therapeutics, 1991
In recent publications we have proposed that dynorphin (Dyn) A(1-17) functions as an antianalgesic modulator to oppose opioid-induced antinociception in mice. In the present experiments using the tail-flick response in mice, other Dyns [Dyn A(1-8), Dyn A(1-13), Dyn A(2-17), Dyn B and alpha- and beta-neoendorphin] when administered intrathecally (i.t ...
J J, Rady, J M, Fujimoto, L F, Tseng
openaire   +2 more sources

Dynorphin A immunoreactivity in human cerebrospinal fluid

Regulatory Peptides, 1987
Dynorphin A immunoreactivity in human cerebrospinal fluid has been characterized. Large quantities of the fluid were fractionated by molecular sieving on a Sephadex G-50 column and analyzed by radioimmunoassay. Active fractions were further analyzed by means of HPLC and an enzyme radioimmunoassay procedure for identification of Leu-enkephalin-Arg6 ...
F, Nyberg, I, Nylander
openaire   +2 more sources

A monoclonal antibody specific for a dynorphin precursor

Neuropeptides, 1985
Murine monoclonal antibodies were produced against dynorphin-32 (D32), a naturally occurring opioid peptide containing the sequence of dynorphin A (Dyn A) at its amino terminus, followed by Lys-Arg, then by the sequence of dynorphin B (Dyn B). Initial characterization using an enzyme-linked immunosorbent assay revealed that one clone (17.M) recognized ...
R W, Barrett, A, Goldstein
openaire   +2 more sources

Differential biotransformation of dynorphin A(1–17) and dynorphin A(1–13) peptides in human blood, ex vivo

Peptides, 1996
The biotransformation in human blood in vitro of three dynorphin A (Dyn A) peptides was studied by matrix assisted laser desorption mass spectrometry to determine whether the natural peptide, Dyn A(1-17), is biotransformed differently from Dyn A (1-13), the natural sequence shortened form used in numerous neurobiological and pharmacological studies. In
J Z, Chou, B T, Chait, R, Wang, M J, Kreek   +3 more
openaire   +3 more sources

Cardiovascular effects of Dynorphin A-(1–8), Dynorphin A-(1–13) and Dynorphin A-(1–17) microinjected into the preoptic medialis nucleus of the rat

Neuropeptides, 1984
Multiple forms of Dynorphin A (Dyn A) are present in cardiovascular nuclei in the hypothalamus, along with kappa-opiate receptors. To study the potential role of Dyn A in cardiovascular regulation, various Dyn A species [Dyn A-(1-8; 1-13; 1-17)] were microinjected into the preoptic nucleus (POM) of the anesthetized rat.
G, Feuerstein, A I, Faden
openaire   +2 more sources

Membrane Interaction of Disease-Related Dynorphin A Variants

Biochemistry, 2013
The membrane interaction properties of two single-residue variants, R6W and L5S, of the 17-amino acid neuropeptide dynorphin A (DynA) were studied by circular dichroism (CD) and nuclear magnetic resonance (NMR) spectroscopy. Corresponding gene mutations have recently been discovered in humans and causatively linked to a neurodegenerative disorder.
Johannes, Björnerås, Astrid, Gräslund, Lena, Mäler   +2 more
openaire   +2 more sources

Dynorphin A(6-12) Analogs Suppress Thermal Edema

Peptides, 1998
Dynorphin A (Dyn A) is a 17-residue opioid peptide derived from prodynorphin precursors found in mammalian tissues. Removal of Tyr1 from Dyn A produces a peptide that is more potent than Dyn A in attenuating the acute phase of the inflammatory response, as measured by inhibition of heat-induced edema in the anesthetized rat's paw (exposure to 58 ...
E T, Wei, H A, Thomas, E A, Gjerde, R K, Reed, S V, Burov, V I, Korolkov, O V, Glynskaya, M Y, Dorosh, G P, Vlasov   +8 more
openaire   +2 more sources