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Tissue distribution of a dynorphin-processing endopeptidase
Endocrinology, 1993A number of peptide hormones and neurotransmitters require post-translational processing at monobasic cleavage sites. An enzymatic activity capable of processing prodynorphin at a monobasic processing site has been previously reported in rat brain and bovine pituitary. This dynorphin (Dyn)-converting enzyme (DCE) activity is capable of converting Dyn-B-
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Peptides, 1994
We previously demonstrated centrally mediated hypotensive and bradycardic effects of dynorphin A(1-8) (DA1-8) on microinjection into various areas of the hippocampal formation (HF) of both anesthetized and conscious male normotensive and spontaneously hypertensive rats (SHR).
J Q, Wang, A J, Ingenito
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We previously demonstrated centrally mediated hypotensive and bradycardic effects of dynorphin A(1-8) (DA1-8) on microinjection into various areas of the hippocampal formation (HF) of both anesthetized and conscious male normotensive and spontaneously hypertensive rats (SHR).
J Q, Wang, A J, Ingenito
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Brain Research, 1984
The distribution of immunoreactive (ir)-dynorphin A1-8 (Dyn A1-8) in 78 microdissected rat brain areas as well as in the neurointermediate lobe of pituitary gland was determined using a highly specific radioimmunoassay. The highest concentrations of Dyn A1-8 in brain were found in substantia nigra (673.8 fmol/mg protein) and lateral preoptic area (565 ...
N, Zamir, M, Palkovits, M J, Brownstein
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The distribution of immunoreactive (ir)-dynorphin A1-8 (Dyn A1-8) in 78 microdissected rat brain areas as well as in the neurointermediate lobe of pituitary gland was determined using a highly specific radioimmunoassay. The highest concentrations of Dyn A1-8 in brain were found in substantia nigra (673.8 fmol/mg protein) and lateral preoptic area (565 ...
N, Zamir, M, Palkovits, M J, Brownstein
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Evidence for dynorphin-A as a neurotransmitter in rat hippocampus
Life Sciences, 1983The molecular forms of Dynorphin A immunoreactivity (Dyn A-IR) detected in hippocampus were resolved by reverse-phase high pressure liquid chromatography (C18-HPLC). Peptide co-eluting with synthetic Dyn A(1-17) represents 20% of the total Dyn A-IR.
C, Chavkin, C, Bakhit, F E, Bloom
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The Journal of Pharmacology and Experimental Therapeutics, 1996
In this study, the ability of a series of dynorphin peptides to inhibit adenylyl cyclase (AC) activity was determined. The endogenous ligand of the kappa opioid receptor, dynorphin A(l-17) (Dyn A(l-17)), produced a significant concentration-dependent inhibition of AC activity in membranes prepared from the caudate putamen (CPu) of naive Fischer 344 ...
L H, Claye +3 more
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In this study, the ability of a series of dynorphin peptides to inhibit adenylyl cyclase (AC) activity was determined. The endogenous ligand of the kappa opioid receptor, dynorphin A(l-17) (Dyn A(l-17)), produced a significant concentration-dependent inhibition of AC activity in membranes prepared from the caudate putamen (CPu) of naive Fischer 344 ...
L H, Claye +3 more
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Dynorphin A Processing Enzyme: Tissue Distribution, Isolation, and Characterization
Journal of Biochemistry, 1999Limited proteolysis of the dynorphin precursor (prodynorphin) at dibasic and monobasic processing sites results in the generation of bioactive dynorphins. In the brain and neurointermediate lobe of the pituitary, prodynorphin is processed to produce alpha and beta neo endorphins, dynorphins (Dyn) A-17 and Dyn A-8, Dyn B-13, and leucine-enkephalin.
Y, Berman +4 more
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A specific radioimmunoassay for the novel opioid peptide dynorphin
Life Sciences, 1980Abstract Dynorphin was recently isolated from porcine pituitary extracts and shown to be the most potent known opioid peptide. Antisera were prepared to synthetic dynorphin-(1–13), the biologically active NH 2 -terminal fragment of the peptide. A high-titer, sensitive antiserum was characterized with fragments from dynorphin-(1–13).
V E, Ghazarossian +2 more
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Analgesic effects of dynorphin-A and morphine in mice
Peptides, 1985To investigate whether or not dynorphin-A is analgesic, the effect of this peptide was tested in comparison with that of morphine in mice. Dynorphin-A produced a potent analgesic effect in the acetic acid writhing and tail pinch tests, but a weak effect in the tail flick test when given by intracerebroventricular injection. In contrast, morphine caused
T, Nakazawa +3 more
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Dynorphin A inhibits NMDA receptors through a pH-dependent mechanism
Molecular and Cellular Neuroscience, 2003Dynorphin A (DynA), an endogenous agonist of kappa-opioid receptors, has also been reported to directly interact with the NMDA receptor. DynA inhibition of NMDA receptor function has been suggested to be involved in its neuroprotective action during ischemic and acidic conditions.
Yoshio, Kanemitsu +6 more
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Metabolism of dynorphin A(1-13).
Die Pharmazie, 2004Dynorphin A(1-13), a tridecapeptide of the endogenous opioid peptides, has modest effects in reducing mild opiate withdrawal in humans. Previous studies revealed that dynorphin also potentiates the analgesic effect of morphine in morphine-tolerant rats and mice.
B, Brugos, G, Hochhaus
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