Results 231 to 240 of about 18,492 (264)
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Characterization of dynorphin A-induced antinociception at spinal level
European Journal of Pharmacology, 1985Dynorphin A (DYN A) injected intrathecally in the rat produced a significant elevation of the nociceptive threshold, measured by the tail flick test. The highest dose of DYN A (25 nmol) produced maximal elevation of tail flick latency to radiant heat together with hindlimb paralysis and tail flaccidity lasting several hours, thus confirming several ...
S, Spampinato, S, Candeletti
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Physical dependence liability of dynorphin A analogs in rodents
European Journal of Pharmacology, 1991To assess the physical dependence liability of dynorphin A analogs, mice were given repeated injections of various dynorphin A analogs twice daily for 5 days, and rats were given repeated administration of [N-methyl-Tyr1,N-methyl-Arg7,D-Leu8]dynorphin-A-(1-8) ethylamide (E-2078) twice daily for up to 7 weeks.
T, Nakazawa +6 more
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Dynorphin modulates motivation through a pallido-amygdala cholinergic circuit
SUMMARYThe endogenous opioid peptide dynorphin and its receptor κ-opioid receptor (KOR) have been implicated in divergent behaviors, but the underlying mechanisms remain elusive. Here we show that dynorphin released from nucleus accumbens dynorphinergic neurons exerts powerful modulation over a ventral pallidum (VP) disinhibitory circuit, thereby ...Qingtao Sun +9 more
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Dynorphin a affects biliary secretion
Pharmacological Research Communications, 1988E. Speroni, E. Cavicchini, S. Ferri
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Morphine acts on spinal dynorphin neurons to cause itch through disinhibition
Science Translational Medicine, 2021Eileen Nguyen, Grace Lim, Huiping Ding
exaly
Nerve fibers containing dynorphin A in cerebral arteries.
Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1995Nerve fibers containing dynorphin (Dyn) A(1-17)-like immunoreactivity were identified around cerebral arteries of guinea pig. The immunoreactive nerve fibers were richly distributed in anterior and middle cerebral arteries, but sparsely in posterior cerebral and basilar arteries. Histofluorescent study showed that large and small cerebral arteries were
J F, Tong +4 more
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A review of some nonopioid actions of dynorphin.
Progress in clinical and biological research, 1986The evidence for several sites of activity within the dynorphin sequence is reviewed. A number of endocrine and CNS peptides are believed to contain several sites of biological activity. Data from a number of laboratories is consistent with such a mechanism for the opioid peptide dynorphin.
J M, Walker +2 more
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