Results 231 to 240 of about 22,550,361 (272)

Distribution of immunoreactive dynorphin A1–8 in discrete nuclei of the rat brain: Comparison with dynorphin A

Brain Research, 1984
The distribution of immunoreactive (ir)-dynorphin A1-8 (Dyn A1-8) in 78 microdissected rat brain areas as well as in the neurointermediate lobe of pituitary gland was determined using a highly specific radioimmunoassay. The highest concentrations of Dyn A1-8 in brain were found in substantia nigra (673.8 fmol/mg protein) and lateral preoptic area (565 ...
Nadav Zamir, M. Palkovits, Michael J. Brownstein   +2 more
openaire   +3 more sources

Effect of intranigral injections of dynorphin, dynorphin fragments and α-neoendorphin on rotational behaviour in the rat

European Journal of Pharmacology, 1984
Peptides deriving from the proenkephalin B precursor were studied in the Ungerstedt rotational model after their unilateral injection into the substantia nigra. Dynorphin (DYN)-(1-17), DYN-(1-13) and DYN-(1-8) in 0.1-10 micrograms doses induced marked contralateral rotation.
Menek Goldstein, Menek Goldstein, Menek Goldstein, Mario Herrera-Marschitz, Mario Herrera-Marschitz, Mario Herrera-Marschitz, Urban Ungerstedt, Urban Ungerstedt, Urban Ungerstedt, L. Terenius, L. Terenius, L. Terenius, Tomas Hökfelt, Tomas Hökfelt, Tomas Hökfelt   +14 more
openaire   +3 more sources

Dynorphin A Peptides

CNS Drugs, 2000
Dynorphin (DYN) is a potent endogenous opioid peptide which binds with high affinity to the κ-opioid receptor and has lower affinity for other opioid and non-opioid [N-methyl-D-aspartate (NMDA)] receptors. This pharmacological profile may explain the conflicting results obtained with DYN in experimental pain models. Most recent literature suggests that
Michael Schäfer, Alexander Brack, Christoph Stein   +2 more
openaire   +2 more sources

Distinct Mechanisms for Activation of the Opioid Receptor-Like 1 and κ-Opioid Receptors by Nociceptin and Dynorphin A

Molecular Pharmacology, 1999
To understand how two structurally analogous ligand-receptor systems, the nociceptin/opioid receptor-like 1 (ORL1) and dynorphin A/κ-opioid receptor 1 (KOR1) systems, achieve selectivity, receptor chimeras were generated and analyzed.
C. Mollereau, L. Moulédous, S. Lapalu, G. Cambois, C. Moisand, J. Butour, J. Meunier   +6 more
semanticscholar   +1 more source

Dynorphin A(1-17)-induced feeding: pharmacological characterization using selective opioid antagonists and antisense probes in rats.

Journal of Pharmacology and Experimental Therapeutics, 2002
Ventricular administration of the opioid dynorphin A(1-17) induces feeding in rats. Because its pharmacological characterization has not been fully identified, the present study examined whether a dose-response range of general and selective opioid ...
Robert M. Silva, H. Grossman, M. Hadjimarkou, G. Rossi, G. Pasternak, R. Bodnar   +5 more
semanticscholar   +1 more source

A monoclonal antibody specific for a dynorphin precursor

Neuropeptides, 1985
Murine monoclonal antibodies were produced against dynorphin-32 (D32), a naturally occurring opioid peptide containing the sequence of dynorphin A (Dyn A) at its amino terminus, followed by Lys-Arg, then by the sequence of dynorphin B (Dyn B). Initial characterization using an enzyme-linked immunosorbent assay revealed that one clone (17.M) recognized ...
Avram Goldstein, Ronald W. Barrett
openaire   +3 more sources

Dynorphins regulate the strength of social memory

Neuropharmacology, 2014
Emotionally arousing events like encounter with an unfamiliar con-species produce strong and vivid memories, whereby the hippocampus and amygdala play a crucial role. It is less understood, however, which neurotransmitter systems regulate the strength of social memories, which have a strong emotional component.
Daniela Mauer, Kerstin Michel, Andras Bilkei-Gorzo, Andreas Zimmer   +3 more
openaire   +3 more sources

Dynorphins in regulation of immune system functions [PDF]

Biochemistry (Moscow), 2014
Dynorphins constitute a family of opioid peptides manifesting the highest affinity for κ-opiate receptors. Immune system cells are known to express a κ-receptor similar to that in the central nervous system, and as a consequence dynorphins are involved in the interaction between cells of the nervous and immune systems. In this review, data on dynorphin
S. V. Gein, S. V. Gein
openaire   +2 more sources

Dynorphins other than dynorphin A(1-17) lack spinal antianalgesic activity but do act on dynorphin A(1-17) receptors.

The Journal of Pharmacology and Experimental Therapeutics, 1991
In recent publications we have proposed that dynorphin (Dyn) A(1-17) functions as an antianalgesic modulator to oppose opioid-induced antinociception in mice. In the present experiments using the tail-flick response in mice, other Dyns [Dyn A(1-8), Dyn A(1-13), Dyn A(2-17), Dyn B and alpha- and beta-neoendorphin] when administered intrathecally (i.t ...
J J, Rady, J M, Fujimoto, L F, Tseng
openaire   +2 more sources

Molecular simulation of dynorphin A-(1-10) binding to extracellular loop 2 of the kappa-opioid receptor. A model for receptor activation.

Journal of Medicinal Chemistry, 1997
The structure of the second extracellular loop region (EL2) of the kappa-opioid receptor has been explored in an effort to understand the structural basis for dynorphin A binding and selectivity.
Germana Paterlini, P. Portoghese, David M. Ferguson   +2 more
semanticscholar   +1 more source