Results 241 to 250 of about 22,550,361 (272)

Dynorphin A immunoreactivity in human cerebrospinal fluid

Regulatory Peptides, 1987
Dynorphin A immunoreactivity in human cerebrospinal fluid has been characterized. Large quantities of the fluid were fractionated by molecular sieving on a Sephadex G-50 column and analyzed by radioimmunoassay. Active fractions were further analyzed by means of HPLC and an enzyme radioimmunoassay procedure for identification of Leu-enkephalin-Arg6 ...
Fred Nyberg, Ingrid Nylander
openaire   +3 more sources

Dynorphin A elicits an increase in intracellular calcium in cultured neurons via a non-opioid, non-NMDA mechanism.

Journal of Neurophysiology, 2000
The opioid peptide dynorphin A is known to elicit a number of pathological effects that may result from neuronal excitotoxicity. An up-regulation of this peptide has also been causally related to the dysesthesia associated with inflammation and nerve ...
Q. Tang, R. Lynch, F. Porreca, J. Lai
semanticscholar   +1 more source

Evidence for dynorphin-A as a neurotransmitter in rat hippocampus

Life Sciences, 1983
The molecular forms of Dynorphin A immunoreactivity (Dyn A-IR) detected in hippocampus were resolved by reverse-phase high pressure liquid chromatography (C18-HPLC). Peptide co-eluting with synthetic Dyn A(1-17) represents 20% of the total Dyn A-IR.
Charles Chavkin, Floyd E. Bloom, C. Bakhit   +2 more
openaire   +3 more sources

Optimization of solid-phase synthesis of [Ala8]-dynorphin A

, 1992
[Ala 8 ]-dynorphin A, a potent k-selective opioid heptadecapeptide with numerous sensitive side-chain residues, has been prepared by solid-phase synthesis using base-labile N α -9-fluorenylmethyloxycarbonyl (Fmoc) protection and side-chain anchoring to a
N. Solé, G. Barany
semanticscholar   +1 more source

Altered extracellular striatal in vivo biotransformation of the opioid neuropeptide dynorphin A(1-17) in the unilateral 6-OHDA rat model of Parkinson's disease.

Journal of Mass Spectrometry, 2005
The in vivo biotransformation of dynorphin A(1-17) (Dyn A) was studied in the striatum of hemiparkinsonian rats by using microdialysis in combination with nanoflow reversed-phase liquid chromatography/electrospray time-of-flight mass spectrometry.
R. Klintenberg, P. Andrén
semanticscholar   +1 more source

Tissue distribution of a dynorphin-processing endopeptidase

Endocrinology, 1993
A number of peptide hormones and neurotransmitters require post-translational processing at monobasic cleavage sites. An enzymatic activity capable of processing prodynorphin at a monobasic processing site has been previously reported in rat brain and bovine pituitary. This dynorphin (Dyn)-converting enzyme (DCE) activity is capable of converting Dyn-B-
openaire   +3 more sources

Characterization of immunoreactive dynorphin in human phaeochromocytomas

Journal of Endocrinology, 1988
ABSTRACT The prodynorphin-derived opioids, dynorphin (DYN) and α-neoendorphin (αNE) were studied in 24 human phaeochromocytomas and related tumours. Nineteen tumours, extracted in HCl (0·1 mol/l), contained concentrations of immunoreactive DYN (ir-DYN) ranging from < 0·5 to 794 pmol/g wet weight. None of the extracts in HCl contained ir-αNE (
G. M. Besser, Trevor A. Howlett, L. H. Rees   +2 more
openaire   +3 more sources

Dynorphin A-mediated reduction in multiple calcium currents involves a G(o) alpha-subtype G protein in rat primary afferent neurons.

Journal of Neurophysiology, 1997
We examined the effect of antisera directed at specific G-protein subtype(s) on dynorphin A (Dyn A)-mediated reduction of calcium currents in rat dorsal root ganglia (DRG) neurons.
J. Wiley, H. C. Moises, R. Gross, R. Macdonald   +3 more
semanticscholar   +1 more source

Cytokine involvement in dynorphin-induced allodynia

Pain, 2000
Dynorphin A is an endogenous opioid peptide, which has previously been shown to produce a long-lasting allodynia and hyperalgesia in mice, behavioral states consistent with signs of clinically observed neuropathic pain. This dynorphin-induced allodynia was used as a pharmacological, central model of neuropathic pain.
Tinna M. Laughlin, George L. Wilcox, Robert P. Yezierski, John R. Bethea   +3 more
openaire   +3 more sources

Orphanin FQ, but not dynorphin A, accelerates colonic transit in rats.

Gastroenterology, 2000
BACKGROUND & AIMS The endogenous opiate receptor-like 1 ligand, orphanin FQ (OFQ), which structurally resembles dynorphin A, has been identified. We investigated the mechanism of action of OFQ in the colon and compared it with that of dynorphin A in vivo.
T. Takahashi, Y. Mizuta, C. Owyang
semanticscholar   +1 more source