Results 191 to 200 of about 9,925 (218)

DYRK1A Kinase Positively Regulates Angiogenic Responses in Endothelial Cells [PDF]

Cell Reports, 2018
Angiogenesis is a highly regulated process essential for organ development and maintenance, and its deregulation contributes to inflammation, cardiac disorders, and cancer. The Ca2+/nuclear factor of activated T cells (NFAT) signaling pathway is central to endothelial cell angiogenic responses, and it is activated by stimuli like vascular endothelial ...
Maria Jose Barallobre, Chiara Di Vona, Carole Jung   +2 more
exaly   +7 more sources

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DYRK1A Kinase Inhibitors with Emphasis on Cancer

Mini-Reviews in Medicinal Chemistry, 2012
Various types of cancers (including gliomas, melanomas, and esophageal, pancreas and non-small-cell lung cancers) display intrinsic resistance to pro-apoptotic stimuli, such as conventional chemotherapy and radiotherapy, and/or the activation of a multidrug resistance phenotype, which are major barriers to effective treatment and lead to poor patient ...
Ionescu, Alexandra, Dufrasne, François, Gelbcke, Michel, Jabin, Ivan, Kiss, Robert, Lamoral-Theys, Delphine   +5 more
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Acridone Alkaloids from Glycosmis chlorosperma as DYRK1A Inhibitors

Journal of Natural Products, 2014
Two new acridone alkaloids, chlorospermines A and B (1 and 2), were isolated from the stem bark of Glycosmis chlorosperma, together with the known atalaphyllidine (3) and acrifoline (4), by means of bioguided isolation using an in vitro enzyme assay against DYRK1A.
Beniddir, Mehdi A., Le Borgne, Erell, Iorga, Bogdan I., Loaëc, Nadège, Lozach, Olivier, Meijer, Laurent, Awang, Khalijah, Litaudon, Marc   +7 more
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Dyrk1A Inhibition as Potential Treatment for Alzheimer’S Disease

Future Medicinal Chemistry, 2016
In total, 47,500,000 people worldwide are affected by dementia and this number is estimated to double by 2030 and triple within 2050 resulting in a huge burden on public health. Alzheimer's disease (AD), a progressive neurodegenerative disorder, is the most common cause of dementia, accounting for 60-70% of all the cases.
Silvia, Stotani, Fabrizio, Giordanetto, Federico, Medda   +2 more
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Regulation of Dyrk1A kinase activity by 14-3-3

Biochemical and Biophysical Research Communications, 2004
Dual-specificity tyrosine(Y) regulated kinase 1A (DYRK1A) is a serine/threonine protein kinase implicated in mental retardation resulting from Down syndrome. In this study, we carried out yeast two-hybrid screening to find proteins regulating DYRK1A kinase activity.
Kim, D, Won, J, Shin, DW, Kang, J, Kim, YJ, Choi, SY, Hwang, MK, Jeong, BW, Kim, GS, Joe, CO Joe, Cheol O, Chung, SH, Song, WJ   +11 more
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Dyrk1a kinase controls cardiomyocyte proliferation

Journal of Molecular and Cellular Cardiology, 2022
Giorgia Rizzari, Ellen Dirkx, Consuelo Torrini, Mateusz Tomczyk, Miguel Mano, Mauro Giacca   +5 more
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CHARACTERIZATION OF THE TSC/DYRK1A INTERACTION

2020
VCU Theses and ...
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DYRK1A inhibitors for disease therapy: Current status and perspectives

European Journal of Medicinal Chemistry, 2022
Tong Liu, Yu-Xi Wang, Jiaxing Wang
exaly  

Inhibition of DYRK1A, via histone modification, promotes cardiomyocyte cell cycle activation and cardiac repair after myocardial infarction

EBioMedicine, 2022
Xuewei Xia, Chunyu Zeng
exaly  

Dyrk1a

AfCS-Nature Molecule Pages, 2008
openaire   +1 more source