Results 131 to 140 of about 1,939 (189)

Deciphering the Formulation‐Dependent Neurotoxicity of Irinotecan: An Integrated Pharmacovigilance and Mechanistic Study

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
Overall workflow of the study, from computational toxicology screening and FAERS‐based data mining to mechanistic prediction of neurotoxicity of irinotecan. ABSTRACT Irinotecan is a key chemotherapeutic agent, but its neurotoxicity limits its utility.
Cheng Shen, Wei Ma, Jing Lu, Yongbo Tang, Wei Cao   +4 more
wiley   +1 more source

Primary CNS Anaplastic Large Cell Lymphoma DUPS22 Rearranged with Gain of ALK: A Case Report and Review of the Literature

eJHaem, Volume 7, Issue 4, August 2026.
ABSTRACT ALK‐negative anaplastic large cell lymphoma (ALCL) is a rare primary central nervous system lymphoma (PCNSL). Although DUSP22 rearrangement is considered favorable in systemic ALK‐negative ALCL, survival remains poor in PCNSL. We report a case of PCNSL ALK‐negative ALCL with DUSP22‐IRF4 rearrangement and an unusual gain of the ALK gene (2p23),
Sindu Iska, María Herrán, Zackary Anderson, Pablo Bejarano, Silvia Bunting, Chieh‐Lin Fu   +5 more
wiley   +1 more source

Glucose Transporter 1 in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
As the quintessential facilitator of basal glucose uptake, glucose transporter 1 (GLUT1) is indispensable for maintaining systemic energy homeostasis. This graphical abstract delineates the multidimensional landscape of GLUT1 in normal physiology. It highlights its tissue‐specific metabolic roles—from fueling erythrocytes and fetal development to ...
Yi Tai, Zhihao Chen, Yuping Zhu, Weidong Han   +3 more
wiley   +1 more source

Voice and Speech in Atypical Parkinsonian Disorders

Movement Disorders Clinical Practice, Volume 13, Issue 8, Page 1848-1860, August 2026.
Background Motor speech disorders are early, common, and functionally limiting features of atypical parkinsonian disorders (APDs) such as progressive supranuclear palsy (PSP), corticobasal syndrome (CBS), and multiple system atrophy (MSA). These impairments are underrecognized and undertreated in neurology clinics.
Federico Rodriguez‐Porcel, Farwa Ali, Michiko Bruno, Heather Davis Cuevas, Rohit Dhall, Kylie Dunne‐Platero, Lawrence I. Golbe, Ihtsham Haq, Nicole Herndon, Lawrence S. Honig, Kyurim Kang, Sarah Kremen, Guillaume Lamotte, Nikolaus R. McFarland, Michela Mir, Leila Montaser‐Kouhsari, Alexander Pantelyat, Joel Page, Hylan Pickett, Laura Purcell Verdun, Kelly Richardson, Jessica Shurer, Michelle Troche, Rene L. Utianski, Katya Villarreal‐Cavazos, Tuhin Virmani, Anne‐Marie Wills, as the Diagnosis and Treatment Working Group, CurePSP Center of Care (CoC) Network, Farwa Ali, Michiko Bruno, Timothy Chang, Rohit Dhall, Kimiko Domoto‐Reilly, Lawrence I. Golbe, Ihtsham Haq, Lawrence S. Honig, Sarah Kremen, Guillaume Lamotte, Zoltan Mari, Nikolaus R. McFarland, Leila Montaser‐Kouhsari, Alexander Pantelyat, Federico Rodriguez‐Porcel, Junaid Siddiqui, Jessica Shurer, Christopher Spears, Tuhin Virmani, Anne‐Marie Wills   +48 more
wiley   +1 more source

Risk‐Benefit Considerations in Deep Brain Stimulation Discontinuation for Late‐Stage Parkinson's Disease

Movement Disorders Clinical Practice, Volume 13, Issue 8, Page 1918-1925, August 2026.
ABSTRACT Background Management of deep brain stimulation (DBS) in late‐stage Parkinson's disease (LSPD) remains challenging, particularly when deciding whether to continue or discontinue stimulation, and evidence on risk–benefit considerations is limited. Objectives To identify key factors to improve decision‐making in DBS management for LSPD patients.
Pietro Antenucci, Andrea Gozzi, Fabiana Colucci, Federica Pes, Jay Guido Capone, Alba Scerrati, Michele Alessandro Cavallo, Maura Pugliatti, Daniela Gragnaniello, Mariachiara Sensi   +9 more
wiley   +1 more source

Longitudinal Videofluorographic Dysphagia Measures in Progressive Supranuclear Palsy

Movement Disorders Clinical Practice, Volume 13, Issue 8, Page 1895-1906, August 2026.
Abstract Background Dysphagia can lead to fatal aspiration pneumonia in progressive supranuclear palsy (PSP). Little is known about the longitudinal progression of dysphagia or whether it differs across PSP clinical variants. Objectives To characterize longitudinal changes in dysphagia across PSP variants and determine relationships with disease ...
Anna Chiara Cattani, Jerusha G. Bhaskaran, Farwa Ali, Julie Stierwalt, Federica Agosta, Massimo Filippi, Keith A. Josephs, Heather M. Clark, Jennifer L. Whitwell   +8 more
wiley   +1 more source

Dysarthria [PDF]

, 2020
openaire   +1 more source

Nurse‐Coordinated and Guideline‐Driven Care in Acute Ischemic Stroke: A Prospective Study With Retrospective Propensity‐Score Matched Controls

Nursing Open, Volume 13, Issue 8, August 2026.
ABSTRACT Aim To evaluate the efficacy of establishing a nurse‐coordinated and guideline‐driven care by advanced stroke nurses for acute ischemic stroke (AIS). Background Specialised nursing care is usually not integrated enough to provide high quality of interdisciplinary care for patients with AIS.
Guili Guo, Lan Gao, Jie Zhao, Hong Chang
wiley   +1 more source

Oral Health Care Services, Barriers and Enablers to Maintaining Good Oral Health in Motor Neurone Disease: A Scoping Review

Community Dentistry and Oral Epidemiology, Volume 54, Issue 4, Page 447-461, August 2026.
ABSTRACT Objectives The objective of this scoping review was to map existing literature on oral health and related care in individuals with Motor Neurone Disease (MND). Specifically, the review aimed to identify barriers and facilitators to maintaining oral hygiene, summarise available clinical guidelines and patient‐facing resources, and examine how ...
Mariam A. Khokhar, Lucy A. O'Malley, Anne‐Marie Glenny, Xiaohui Chen   +3 more
wiley   +1 more source

IgG4‐Related Disease Overlapping With Anti‐Acetylcholine Receptor Antibody–Positive Myasthenia Gravis

Clinical and Experimental Neuroimmunology, Volume 17, Issue 3, August 2026.
ABSTRACT Background IgG4‐related disease (IgG4‐RD) is a systemic, immune‐mediated, fibroinflammatory disorder with multiorgan involvement and variable clinical presentation, often creating diagnostic difficulty. Myasthenia gravis (MG) is an antibody‐mediated autoimmune disorder of the neuromuscular junction, most commonly associated with anti ...
Yumiko Yoshida, Ayami Okuzumi, Yuka Hosaka, Yuji Tomizawa, Taku Hatano   +4 more
wiley   +1 more source