Results 21 to 30 of about 37,093 (216)

Two Distinct Clinical Phenotypes of Bulbar Motor Impairment in Amyotrophic Lateral Sclerosis

Frontiers in Neurology, 2021
Objective: Understanding clinical variants of motor neuron diseases such as amyotrophic lateral sclerosis (ALS) is critical for discovering disease mechanisms and across-patient differences in therapeutic response. The current work describes two clinical
Kaila L. Stipancic, Kaila L. Stipancic, Yana Yunusova, Thomas F. Campbell, Jun Wang, James D. Berry, Jordan R. Green   +6 more
doaj   +1 more source

Characteristics of Dysarthria in Post-Stroke Patients [PDF]

Multidisciplinarni Pristupi u Edukaciji i Rehabilitaciji
Dysarthria is a motor speech disorder caused by damage to the central nervous system. It is characterized by uncoordinated movements of the orofacial muscles. Several types of dysarthria can develop as a consequence of stroke, traumatic brain injury, and
Sofija Bajagić, Mile Vuković
doaj   +1 more source

Variant ataxia-telangiectasia in a child presenting with laryngeal dystonia

The Turkish Journal of Pediatrics, 2020
Background. Dystonia is a common hyperkinetic movement disorder in children; however, making an early and definitive diagnosis of dystonia can sometimes be challenging for clinicians. Case.
Pınar Arıcan, Nihal Olgaç Dündar, Özgür Kırbıyık, Dilek Çavusoğlu, Sema Bozkaya Yılmaz, Pınar Gençpınar   +5 more
doaj   +1 more source

Stroke-associated dysarthria

Frontiers in Neurology
A stroke can damage various regions of the brain. Damage to the upper motor neurons of the pyramidal tracts causes unilateral upper motor neuron dysarthria or spastic dysarthria.
Lan-Xin Lin, Lan-Xin Lin, Shun-Yu Yao, Shun-Yu Yao, Quan Chen, Quan Chen, Miao-Qiao Du, Miao-Qiao Du, Xu-Hui Kang, Xu-Hui Kang, Dai-Yi Jiang, Dai-Yi Jiang, Yong Peng, Yong Peng   +13 more
doaj   +1 more source

Clinical Spectrum and Outcomes of SOX1 Antibody‐Associated Paraneoplastic Neurological Syndromes: A Chinese Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background SOX1 antibody‐positive paraneoplastic neurological syndromes (PNS) exhibit significant population‐specific clinical heterogeneity. While Western cohorts predominantly manifest Lambert‐Eaton myasthenic syndrome (65%–80%), comprehensive clinical characterization and treatment response data in Asian populations remain critically ...
Jin‐Long Ye, Zu‐Ying Kuang, Bo Li, Meng‐Qiu Pan, Li‐Hua Zhou, Yang‐Yang Dai, Si‐Fen Xie, Xian‐Guang Lin, Ye‐Peng Hu, Li‐Hong Jiang, Zhan‐Hang Wang, Wei‐Jing Zhang   +11 more
wiley   +1 more source

Alternative and Augmentative Communication in Amyotrophic Lateral Sclerosis Patients

Listy klinicke logopedie, 2022
Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disease. Among others, dysarthria and dysphagia (i.e. bulbar dysfunction) represent common clinical manifestations of ALS. Gradual impairment or even loss of speech functions puts ALS
Naděžda Lasotová, Adam Betík, Eva Vlčková   +2 more
doaj   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Automatic Speech Recognition in Noise for Parkinson's Disease: A Pilot Study

Frontiers in Artificial Intelligence, 2021
The sophistication of artificial intelligence (AI) technologies has significantly advanced in the past decade. However, the observed unpredictability and variability of AI behavior in noisy signals is still underexplored and represents a challenge when ...
Alireza Goudarzi, Gemma Moya-Galé
doaj   +1 more source

GAD65 Antibody ELISA With Extended Reportable Range: Validation and Guidance for Neurological Practice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To (1) validate GAD65‐ELISA detection and quantification for type 1 diabetes mellitus and autoimmune neurological diagnoses, (2) correlate ELISA results (reference range < 5 IU/mL) with established radioimmunoprecipitation assay (RIA; ≤ 0.02 nmol/L), and (3) define ELISA clinical utility and pitfalls.
Andrew McKeon, Dana Olofson, Diana Anissian, Divyanshu Dubey, Eoin P. Flanagan, Max C. Herman, Sarosh R. Irani, Daniel H. Lachance, Maria A. Willrich, Sean Pittock, John R. Mills, Anastasia Zekeridou   +11 more
wiley   +1 more source

Oromotor Nonverbal Performance and Speech Motor Control: Theory and Review of Empirical Evidence

Brain Sciences, 2023
This position paper offers a perspective on the long-standing debate concerning the role of oromotor, nonverbal gestures in understanding typical and disordered speech motor control secondary to neurological disease. Oromotor nonverbal tasks are employed
Gary Weismer
doaj   +1 more source