Results 41 to 50 of about 16,532 (175)

Higher risk of Long COVID among patients with autoimmune rheumatic diseases and immunomodulatory therapy: a retrospective cohort analysis of national US data.

Arthritis &Rheumatology, Accepted Article.
Background Little is known about the prevalence of and factors associated with Long COVID in patients with autoimmune rheumatic diseases (AIRDs). Methods We conducted a retrospective cohort study using data from the National Clinical Cohort Collaborative (N3C).
Namrata Singh, A. Jerrod Anzalone, Holland Stevenson, Londyn Robinson, Lesley E. Jackson, Sandra E. Safo, Zachary Butzin‐Dozier, Kaleb Michaud, Maria I. Danila, Jasvinder A. Singh, Rena C. Patel, on behalf of the National Clinical Cohort Collaborative (N3C) Consortium   +11 more
wiley   +1 more source

Paediatric clonidine medication errors: Findings from a multicentre French study

British Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to describe the characteristics of medication errors involving clonidine in paediatric patients and reported to French Network of Pharmacovigilance and Poison Control Centres. Methods This retrospective observational study analysed clonidine‐related medication errors reported between 1985 and June 2024 in patients under 12 years ...
Eve‐Marie Thillard, Anthony Facile, Marion Lepelley, Morgane Cellier, Laurent Chouchana, Sophie Gautier, Ramy Azzouz, Thierry Vial, Annie‐Pierre Jonville‐Bera   +8 more
wiley   +1 more source

Clinical Model‐Informed Precision Dosing Consult Service for Accelerating Personalized Medication in Pediatric Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Traditional dosing strategies often rely on a “one‐size‐fits‐all” paradigm, assuming an “average” patient with typical demographic and pharmacological characteristics. In reality, this often overlooks existing between‐patient variability and can lead to suboptimal drug exposure or toxicity. This issue is especially pronounced in pediatric patients, who
Zachary L. Taylor, Takanobu Nadai, Kei Irie, Wen Rui Tan, Sanjana Parikh, Anhar Hosawi, Matthijs W. van Hoogdalem, Ronaldo Morales Junior, Sonya Tang Girdwood, Abbie D. Leino, Kana Mizuno, Alexander A. Vinks, Tomoyuki Mizuno   +12 more
wiley   +1 more source

Proteomic profiling of Elp1‐deficient trigeminal ganglia reveals disruption of neurotrophic and metabolic pathways in a familial dysautonomia mouse model

Developmental Dynamics, EarlyView.
Abstract Background Elp1, a subunit of the Elongator complex, is essential for tRNA modification and neuronal development. Mutations in ELP1 underlie familial dysautonomia (FD), a disorder marked by sensory and autonomic neuropathy. While loss of Elp1 disrupts trigeminal ganglion formation and survival, the downstream molecular consequences remain ...
Carrie E. Leonard, Lauren Clarissa Tang, Beatrix Ueberheide, Lisa A. Taneyhill   +3 more
wiley   +1 more source

NMDAR‐antibody encephalitis: Seizure semiology and EEG findings

Epileptic Disorders, EarlyView.
Abstract Background N‐methyl‐D‐aspartate receptor antibody encephalitis (NMDAR‐Ab‐E) is an autoantibody‐mediated disorder, characterized by acute development of neuropsychiatric symptoms, seizures, movement disorders, and autonomic instability. Objectives To describe acute seizure semiology and electroencephalogram (EEG) findings in patients with a ...
Maria Emilia C. Andraus, Bernard Liem, Sidra Aurangzeb, Mkael Symmonds, Adam E. Handel, Sarosh R. Irani, Arjune Sen   +6 more
wiley   +1 more source

Paroxysmal hyperthermia, dysautonomia and rhabdomyolysis in a patient with Lesch–Nyhan syndrome

JIMD Reports, 2021
Lesch–Nyhan syndrome is an x‐linked genetic disorder of purine metabolism that results in the overproduction of uric acid and neurologic deficits manifesting as intellectual disability, dystonia, other movement disorders and self‐mutilation.
Mandeep Rana, Karen Cuttin, Gerard T. Berry, Alcy Torres   +3 more
doaj   +1 more source

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Neurological Entity?

Medicina, 2021
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a disorder of unknown physiopathology with multisystemic repercussions, framed in ICD-11 under the heading of neurology (8E49).
Iñigo Murga Gandasegui, Larraitz Aranburu Laka, Pascual-Ángel Gargiulo, Juan-Carlos Gómez-Esteban, José-Vicente Lafuente Sánchez   +4 more
doaj   +1 more source

The psychophysiology of dysautonomia [PDF]

, 2016
Modern theories of emotion emphasise the role of homeostatic requirements in motivating and shaping behaviour and link emotions with motor and autonomic responses to define physiological, behavioural and neurobiological phenomena initiated by the ...
Owens, AP
core  

Multiple System Atrophy Without Dysautonomia [PDF]

Background and Objectives Multiple system atrophy (MSA) is a neurodegenerative disorder characterized by 3 core symptom complexes: parkinsonism, cerebellar syndrome, and dysautonomia.
Höglinger, Günter U., Pantelyat, Alexander, Compta, Yaroslau, Downes, Sophia, Seemiller, Joseph, Van Swieten, John C., Nemati, Mojtaba, Lang, Anthony E., Lee, Edward B., Bernhardt, Alexander Maximilian, Herms, Jochen, Ruf, Viktoria Constanze, Kovacs, Gabor G., Bebermeier, Sarah, Berger, Stephen, Troakes, Claire, Swieten, John C. Van, Cohen, Jesse, Dopper, Elise G.P., Heine, Johanne, Irwin, David John, Wilkens, Ida, Vamanu, Albert, Levin, Johannes, Katzdobler, Sabrina, Bendahan, Nathaniel, Rozemuller, Annemieke J.M., Hopfner, Franziska, Molina Porcel, Laura, Nilsson, Christer F., Englund, Elisabet M., Englund, Elisabet M.,, Heine, Johanne,, Compta, Yaroslau,, Downes, Sophia,, Lee, Edward B.,, Bernhardt, Alexander Maximilian,, Hopfner, Franziska,, Pantelyat, Alexander,, Bebermeier, Sarah,, Vamanu, Albert,, Kovacs, Gabor G.,, Berger, Stephen,, Höglinger, Günter U.,, Dopper, Elise G.P.,, Cohen, Jesse,, Nemati, Mojtaba,, Lund University., Nilsson, Christer F.,, Wilkens, Ida,, Bendahan, Nathaniel,, Van Swieten, John C.,, Irwin, David John,, Troakes, Claire,, Katzdobler, Sabrina,, Seemiller, Joseph,, Herms, Jochen,, Molina Porcel, Laura,, Levin, Johannes,, Rozemuller, Annemieke J.M.,, Lang, Anthony E.,, Ruf, Viktoria Constanze,   +61 more
core   +1 more source

Gut microbiome dysbiosis drives metabolic dysfunction in Familial dysautonomia

, 2023
Familial dysautonomia is a rare genetic disease caused in part by neurodegeneration. Here, the authors show that the gut-metabolism axis is altered in both patients and transgenic mice and that disease pathology is ameliorated by controlling microbiome ...
Annie Waldum, Susan C. Broadaway, Stephanann M. Costello, Lucy Norcliffe-Kaufmann, Brian Tripet, Marc Mergy, Brian Bothner, Nicholas V. Pinkham, Horacio Kaufmann, Douglas J. Kominsky, Jesse T. Peach, Seth T. Walk, Frances Lefcort, Alexandra M. Cheney, Valérie Copié, Maria Cotrina-Vidal, Heather M. Grifka-Walk   +16 more
core   +1 more source