Results 41 to 50 of about 16,160 (225)

Multiple System Atrophy Without Dysautonomia [PDF]

Background and Objectives Multiple system atrophy (MSA) is a neurodegenerative disorder characterized by 3 core symptom complexes: parkinsonism, cerebellar syndrome, and dysautonomia.
Höglinger, Günter U., Pantelyat, Alexander, Compta, Yaroslau, Downes, Sophia, Seemiller, Joseph, Van Swieten, John C., Nemati, Mojtaba, Lang, Anthony E., Lee, Edward B., Bernhardt, Alexander Maximilian, Herms, Jochen, Ruf, Viktoria Constanze, Kovacs, Gabor G., Bebermeier, Sarah, Berger, Stephen, Troakes, Claire, Swieten, John C. Van, Cohen, Jesse, Dopper, Elise G.P., Heine, Johanne, Irwin, David John, Wilkens, Ida, Vamanu, Albert, Levin, Johannes, Katzdobler, Sabrina, Bendahan, Nathaniel, Rozemuller, Annemieke J.M., Hopfner, Franziska, Molina Porcel, Laura, Nilsson, Christer F., Englund, Elisabet M.   +30 more
core   +1 more source

Paediatric clonidine medication errors: Findings from a multicentre French study

British Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to describe the characteristics of medication errors involving clonidine in paediatric patients and reported to French Network of Pharmacovigilance and Poison Control Centres. Methods This retrospective observational study analysed clonidine‐related medication errors reported between 1985 and June 2024 in patients under 12 years ...
Eve‐Marie Thillard, Anthony Facile, Marion Lepelley, Morgane Cellier, Laurent Chouchana, Sophie Gautier, Ramy Azzouz, Thierry Vial, Annie‐Pierre Jonville‐Bera   +8 more
wiley   +1 more source

Clinical Model‐Informed Precision Dosing Consult Service for Accelerating Personalized Medication in Pediatric Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Traditional dosing strategies often rely on a “one‐size‐fits‐all” paradigm, assuming an “average” patient with typical demographic and pharmacological characteristics. In reality, this often overlooks existing between‐patient variability and can lead to suboptimal drug exposure or toxicity. This issue is especially pronounced in pediatric patients, who
Zachary L. Taylor, Takanobu Nadai, Kei Irie, Wen Rui Tan, Sanjana Parikh, Anhar Hosawi, Matthijs W. van Hoogdalem, Ronaldo Morales Junior, Sonya Tang Girdwood, Abbie D. Leino, Kana Mizuno, Alexander A. Vinks, Tomoyuki Mizuno   +12 more
wiley   +1 more source

Dysautonomia in Alzheimer\u27s Disease

, 2020
Alzheimer\u27s disease is the most common neurodegenerative disorder, and its prevalence increases with age. Although there is a large amount of scientific literature focusing on Alzheimer\u27s disease cardinal cognitive features, autonomic nervous ...
Liviu Cozma, Eugenia Irene Davidescu, Delia Tulbă, Bogdan Ovidiu Popescu   +3 more
core   +1 more source

Proteomic profiling of Elp1‐deficient trigeminal ganglia reveals disruption of neurotrophic and metabolic pathways in a familial dysautonomia mouse model

Developmental Dynamics, EarlyView.
Abstract Background Elp1, a subunit of the Elongator complex, is essential for tRNA modification and neuronal development. Mutations in ELP1 underlie familial dysautonomia (FD), a disorder marked by sensory and autonomic neuropathy. While loss of Elp1 disrupts trigeminal ganglion formation and survival, the downstream molecular consequences remain ...
Carrie E. Leonard, Lauren Clarissa Tang, Beatrix Ueberheide, Lisa A. Taneyhill   +3 more
wiley   +1 more source

Case report: Perioperative management of a patient with familial dysautonomia

, 2021
Familial dysautonomia is a rare autosomal recessive neurodegenerative disease affecting cells of the autonomic nervous system. Patients with this disease are insensitive to pain but their autonomic nervous system is still activated with noxious stimuli ...
Minnea Kalra, Melodie Sarebanha, A Joseph Layon, Laura Valente, Ettore Crimi*   +4 more
core   +1 more source

Imaging findings in 11 cats with feline dysautonomia

, 2010
Dysautonomia is caused by degeneration of the autonomic ganglia. Failure of the autonomic system affecting the gastrointestinal and urinary tracts can cause oesophageal distension and/or dysfunction, gastric and bowel distension and hypomotility, and ...
Simpson, Kerry E., Hammond, Gawain J.C., Gunn-Moore, Danièlle A., Novellas, Rosa, Novellas, Ross   +4 more
core   +2 more sources

NMDAR‐antibody encephalitis: Seizure semiology and EEG findings

Epileptic Disorders, EarlyView.
Abstract Background N‐methyl‐D‐aspartate receptor antibody encephalitis (NMDAR‐Ab‐E) is an autoantibody‐mediated disorder, characterized by acute development of neuropsychiatric symptoms, seizures, movement disorders, and autonomic instability. Objectives To describe acute seizure semiology and electroencephalogram (EEG) findings in patients with a ...
Maria Emilia C. Andraus, Bernard Liem, Sidra Aurangzeb, Mkael Symmonds, Adam E. Handel, Sarosh R. Irani, Arjune Sen   +6 more
wiley   +1 more source

Dysautonomia: Recommendations from A to Z [PDF]

Dysautonomia is an intricate and sometimes misconstrued condition that impacts the autonomic nerve system, which is accountable for controlling involuntary biological functions such as heart rate, blood pressure, and digestion.
Zar, Ronel M
core   +1 more source

Paroxysmal hyperthermia, dysautonomia and rhabdomyolysis in a patient with Lesch–Nyhan syndrome

JIMD Reports, 2021
Lesch–Nyhan syndrome is an x‐linked genetic disorder of purine metabolism that results in the overproduction of uric acid and neurologic deficits manifesting as intellectual disability, dystonia, other movement disorders and self‐mutilation.
Mandeep Rana, Karen Cuttin, Gerard T. Berry, Alcy Torres   +3 more
doaj   +1 more source