Results 221 to 230 of about 132,138 (294)

Integrative host–microbiome modeling uncovers the implication of oral–gut translocation in advanced cirrhosis

open access: yesiMeta, EarlyView.
Liver cirrhosis is associated with profound disruption of host–microbiome metabolic interactions. Using paired oral and fecal metagenomics combined with genome‐scale metabolic modeling, we investigated how microbial translocation along the oral–gut axis influences microbial metabolism at different cirrhosis severities.
Yi Jin   +21 more
wiley   +1 more source

Microbial keystone taxa and metabolic signatures in centenarians regulate intestinal homeostasis during aging

open access: yesiMeta, EarlyView.
Clostridium scindens and its metabolite indole‐3‐acetic acid (IAA) are identified as a keystone taxon and metabolic signature in centenarians. Clostridium scindens enhances microbial network stability and produces IAA via its own amidase (AMIE) and aldehyde dehydrogenase (ALDH), thus promoting intestinal homeostasis by activating the aryl hydrocarbon ...
Wei‐Chuan Lin   +13 more
wiley   +1 more source

Early gut microbial and metabolic dysregulation with subclinical cardiac alterations in a nonhuman primate model of Rett syndrome

open access: yesiMeta, EarlyView.
Longitudinal multi‐omics profiling of a nonhuman primate Rett syndrome (RTT) model reveals early systemic alterations. RTT monkeys exhibited postnatal growth retardation, intestinal structural abnormalities, and low‐grade systemic inflammation. Gut microbiome analysis showed delayed microbial maturation and age‐discordant dysbiosis, including altered ...
Ting Zhang   +8 more
wiley   +1 more source

The role of human microbiota in breast cancer pathogenesis and treatment

open access: yesiMeta, EarlyView.
The human microbiota contributes to breast cancer pathogenesis and treatment response through interactions involving the oral, gut, and breast microbial niches. (Left) Multi‐site dysbiosis is characterized by altered microbial composition and abundance across different anatomical sites.
Jie Qiu   +9 more
wiley   +1 more source

Representing dental caries and dysbiosis within the oral microbiome in the Oral Health and Disease Ontology. [PDF]

open access: yesJ Biomed Semantics
Duncan WD   +6 more
europepmc   +1 more source

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